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| 胆管癌组织中自发性细胞凋亡现象的研究 | |
| 引用本文： | 张丰深,何振平,马宽生. 胆管癌组织中自发性细胞凋亡现象的研究[J]. 中国肿瘤临床, 2002, 29(6): 381-383 |
| 作者姓名： | 张丰深 何振平 马宽生 |
| 作者单位： | 1. 解放军324医院腹部外科,重庆市 2. 第三军医大学附属西南医院全军肝胆外科研究所,重庆市,400038 |
| 基金项目： | 本文课题受国家自然科学基金资助(编号:39670711) |
| 摘 要： | 目的：探讨血管癌组织中自发笥细胞凋亡现象的意义。方法：TUNEL染色结合形态观察原位检测凋亡细胞。结果：40例胆管癌标本的中位SAI高达7．89％，高／中分化和无淋巴结转移胆管癌的SAI分别显著高于低分化和淋巴结转移者（P＜0．001）。结论：胆管癌仍保护有相对活跃的细胞凋亡机制，SAI可作为判断胆管癌恶性程度的有益指标。 |
| 关 键 词： | 胆管癌 自发性细胞凋亡指数 细胞凋亡 SAI |
| 文章编号： | 1000-8179(2002)06-0381-03 |
| 修稿时间： | 2001-11-02 |
A Study on Spontaneous Apoptosis in Cholangiocarcinoma |
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| Zhang Fengshen He Zhenping Ma Kuansheng et al Institute of Hepatobiliary Surgery of PLA,Southwest Hospital,Third Military Medical University,Chongqing. A Study on Spontaneous Apoptosis in Cholangiocarcinoma[J]. Chinese Journal of Clinical Oncology, 2002, 29(6): 381-383 | |
| Authors: | Zhang Fengshen He Zhenping Ma Kuansheng et al Institute of Hepatobiliary Surgery of PLA Southwest Hospital Third Military Medical University Chongqing |
| Abstract: | Objective:To investigate the clinicopathological significance of spontaneous apop-tosis in cholangiocarcinoma.Methods:TUNEL staining technique was conducted to determine apoptotic cells in situ in cholangiocarcinoma tissues.Results:The median of spontaneous apop-totic index(SAI)was up to7.89%in40cases of cholangiocarcinoma,and the SAIs in cases well differentiated and without lymph node metastasis were significantly higher than those in cases poorly differentiated and with lymph node metastasis respectively(P<0.001).Con clusion:The apoptosis mechanism is well preserved in cholangiocarcinoma,and SAI is potentially useful to pre-dict the malignant grade of cholangiocarcinoma. |
| Keywords: | Cholangiocarcinoma Apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |