| p27、cyclin D1与恶性肿瘤 |
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| 引用本文： | 李静,尹林林.p27、cyclin D1与恶性肿瘤[J].国际肿瘤学杂志,2008,35(5). |
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| 作者姓名： | 李静 尹林林 |
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| 作者单位： | 1. 山东省肿瘤防治研究院内三科,济南,250117
2. 济南市第四人民医院 |
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| 摘 要： | 细胞周期调控紊乱是恶性肿瘤发生、发展的主要原因之一,其中,蛋白p27与cyclin D1在细胞周期调控中发挥了重要作用.p27与cyclinD1是细胞周期正负调控因子.p27蛋白在多数肿瘤中低表达或不表达,而cyclinD1蛋白多呈高表达,它们与恶性肿瘤的发生、发展关系密切.目前细胞周期及其调控机制与肿瘤的关系已成为研究热点.
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| 关 键 词： | 肿瘤 细胞周期蛋白D1 细胞周期 |
p27、cyclinD1 and malignant cancer |
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| LI Jing,YIN Lin-lin.p27、cyclinD1 and malignant cancer[J].Journal of International Oncology,2008,35(5). |
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| Authors: | LI Jing YIN Lin-lin |
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| Abstract: | The genesis of malignant tumor is proved to be mainly caused by regulatory disturbance of cell cycle,in which p27 protein and cyclin D1 protein are major regulators.Cyclin D1 and p27 are positive andnegative regulator respeetively.Recently,redueed expression of p27 protein and overexpression of cyclinD1 pro-tein are found in various eaacers.It has been demonstrated that p27and cyelinD1 are closely associated with the genesis and development of many cancers.Cell cycle and its regulatory has become the focus in tumor research. |
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| Keywords: | Neoplasms CyclinD1 Cell cycle |
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