首页 | 本学科首页   官方微博 | 高级检索  
     


Potential celiac disease in type 1 diabetes: a multicenter study
Authors:Franzese Adriana,Iafusco Dario,Spadaro Raffaella,Cavaliere Olmina,Prisco Francesco,Auricchio Renata,Troncone Riccardo,Valerio Giuliana  Study-Group on Diabetes of Italian Society of Pediatric Endocrinology  Diabetology
Affiliation:a Department of Pediatrics, Federico II University, Via S. Pansini 5, 80131 Naples, Italy
b Department of Pediatrics, Second University, Naples, Italy
c School of Movement Sciences (DiSIST), Parthenope University, Naples, Italy
Abstract:

Aims

To describe the prevalence of potential celiac disease (pot-CD) in young patients with type 1 diabetes mellitus (T1DM) and characterize their clinical features.

Methods

This cross-sectional multicenter study involved 8717 T1DM patients from 31 Italian centers. Information was collected on the total number of T1DM patients, CD patients and pot-CD patients. The following data were collected on pot-CD patients: gender, age at T1DM diagnosis, age at the first CD serological positivity, presence of CD-related symptoms, presence of other autoimmune disorders and treatment with gluten free diet (GFD). One thousand-three-hundred-sixty-one patients who were positive for CD serology were the control group.

Results

CD serological positivity was found in 7.2% T1DM patients. Prevalence of pot-CD was 12.2% (n = 77) among CD positive patients: symptoms were present in 12/77; a third autoimmune disorder was found in 15 patients. Prevalence of pot-CD in the control population was 8.4% (n = 114; p = 0.005). No difference was found with regard to clinical features. Only few symptomatic patients were on GFD both in T1DM and control patients.

Conclusions

A higher prevalence of pot-CD was found in T1DM patients, that may be ascribed to the routine screening, although the influence of genetic factors cannot be excluded.
Keywords:Autoimmune disorders   Celiac disease   Potential celiac disease   Type 1 diabetes
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号