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| 荆芥内酯类提取物对大鼠足跖汗腺及血液流变学的影响 | |
| 引用本文： | 卢金福 冯有龙 等. 荆芥内酯类提取物对大鼠足跖汗腺及血液流变学的影响[J]. 中国药科大学学报, 2002, 33(6): 502-504 |
| 作者姓名： | 卢金福 冯有龙 等 |
| 作者单位： | 1. 南京中医药大学国家规范化中药药理实验室,南京,210029 2. 江苏省药品检验所,南京,210008 3. 江苏省中医院,南京,210029 |
| 基金项目： | "九五"攻关,中药材荆芥质量标准的规范化研究(96-903-02-03) |
| 摘 要： | 目的 观察荆芥内酯类提取物对汗腺及血液流变学的影响。方法 大鼠腹腔注射给药1h后,自踝关节处迅速取下双后足,10%甲醛溶液固定,对足跖部汗腺腺泡上皮细胞在光镜下作形态学观察。大鼠血（肝素抗凝）用于血液流变学测定。结果 荆芥内酯类提取物能明显提高汗腺腺泡上皮细胞的空泡发生率,数密度和面密度,显著降低全血比粘度和红细胞的聚集性。结论 荆芥内酯类提取物具有显著的发汗和改善血液流变学的作用。 |
| 关 键 词： | 荆芥 荆芥内酯类提取物 发汗 血液流变学 中药动物实验 |
| 文章编号： | 1000-5048(2002)06-0502-03 |
Impact of Lactones of Schizonepeta Tenuifolia Briq. on Plantar Sweat Gland and Hemorrheology of Rats |
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| LU Jin-Fu,ZHANG Li,FENG You-Long,DING An-Wei,DU Ping School of Materia Medic,Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu Provincial Institute For Drugs Control,Nanjing,Pharmacy Section,Jiangsu P. Impact of Lactones of Schizonepeta Tenuifolia Briq. on Plantar Sweat Gland and Hemorrheology of Rats[J]. Journal of China Pharmaceutical University, 2002, 33(6): 502-504 | |
| Authors: | LU Jin-Fu ZHANG Li FENG You-Long DING An-Wei DU Ping School of Materia Medic Nanjing University of Traditional Chinese Medicine Nanjing Jiangsu Provincial Institute For Drugs Control Nanjing Pharmacy Section Jiangsu P |
| Affiliation: | LU Jin-Fu,ZHANG Li,FENG You-Long 1,DING An-Wei,DU Ping 2 School of Materia Medica,Nanjing University of Traditional Chinese Medicine,Nanjing 210029, 1Jiangsu Provincial Institute For Drugs Control,Nanjing 210008, 2Pharmacy Section,Jiangsu Provincial TCM Hospital,Nanjing 210029,China |
| Abstract: | AIM To assess the impact of the lactones of Schizonepeta tenuifolia Briq. (LST) on plantar sweat gland and hemorrheology of rats. METHODS The double metapodia of the rats were cut immediatedly at the ankle joint at 1 h after intraperitoneal injection of LST and evaluated the morphological alteration of acinus epicyte of the plantar sweat gland by light microscopy. The anticoagulant blood was used in the determination of hemorrhology. RESULTS LST significantly increased the incidence, number density and area density of the vacuole of the acinus epicyte of the plantar sweat gland, and decreased the whole blood specific viscosity and RBC aggregation. CONCLUSION LST significantly promotes diaphoresis and ameliorates hemorrheology. |
| Keywords: | Schizonepeta tenuifolia Briq. Lactones of Schizonepeta tenuifolia Briq. Diaphoresis Hemorrheology |
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