尿中1-羟基芘作为焦炉工多环芳烃暴露生物监测指标的研究

目的探讨焦炉工外暴露等级与尿中1-羟基芘(1-OHPy)浓度的关系。方法以某焦化厂120名生产工人和30名非接触者为研究对象,收集班后6h尿,并收集个人信息,用高效液相法测定尿中1-羟基芘。结果尿中1-羟基芘浓度呈炉顶>炉侧>炉底>对照组的趋势。与外暴露呈显著相关性(r=0.653,P<0.01),同样外暴露条件下,吸烟者尿中1-羟基芘显著高于未吸烟者(P<0.05)。结论焦炉工尿中1-羟基芘水平与外暴露等级存在明显的相关性,可反映多环芳烃暴露个体的内剂量水平。

Study on Urinary 1-hydroxypyrene concentrations in coke oven workers could be used as biomarker to evalute Polycyclic aromatic hydrocarbon exposure of coke oven workers

Objective TO investigate the relationship between the external exposure categories and urinary 1-hydroxypyrene concentrations in coke oven workers.Methods 120 coke oven worker from a coke oven plant and 30 controls were enrolled into this study.Spot urine samples were obtained at the end of a work 6 hours and personal information was collected by quesfionnake.A method of alkaline hydrolysis combined with high performance liquid chromatography was employed to measure 1-hydroxypyrene in urine.Results Significant correlation was found between external exposure categories and urinary 1hydroxypyrene concentrations(Spearman correlation coefficient=0.653,P<0.01).When adjsted for external exposure,smoking significantly influence urinary 1-hydroxypyrene concentrations(P<0.01).Conclusions There is a signficant association between external exposure categories and urinary 1-hydroxypyrene concentrations in coke oven workers.Urinary 1-hydroxypyrene concentrations in coke oven workers could be used aS biomarker to evaluate PAHs exposure of coke oven workers.