原发性皮肤间变性大细胞淋巴瘤一例

［摘要］报告1例原发性皮肤CD30+大细胞性淋巴瘤。右前臂皮肤红肿浸润、溃疡结痂1月，左侧头面部红肿浸润10天。右前臂皮损组织病理检查：真皮深层以及皮下脂肪组织间瘤细胞浸润，密集分布。瘤细胞胞质丰富，呈嗜酸性，部分呈空泡状，细胞核大，异型性明显，核仁明显，染色质呈粗颗粒状，并可见病理性核分裂象；有少量成熟淋巴细胞浸润。行免疫组化检查示： 瘤细胞CD45R0（+）、CD30（+），CD68（－）、CD20（-）、EMA（-）及ALK（-）。诊断为原发性皮肤间变性大细胞淋巴瘤

A case of primary cutaneous anaplastic large cell lymphoma

This paper reports one case of primary cutaneous CD30 + large cell lymphoma. The right forearm skin appears inflammation, infiltration and ulcer incrustation for one month; the left head and face appear inflammation and infiltration for ten days. Pathological examination on right forearm cutaneous lesions: at the deep dermal layer and between subcutaneous adipose tissues the tumor cells appear infiltration and intensive distribution; the tumor cells are rich in cytoplasm and are eosinophilic; some show vacuoles shape, big nucleus, obvious atypia and obvious nucleoli, the chromatin showing coarse granular shape, and there is pathological karyokinesis; a small amount of sophisticated lymphocytic appear infiltration. Immunohistochemistrical examination shows tumor cells CD45R0 (+), CD30 (+), CD68 (-), CD20 (-), EMA (-) and ALK (-). Thus it is diagnosed as Primary Cutaneous Anaplastic Large Cell Lymphoma