| 降钙素基因相关肽和内皮素-1在大鼠急性肾功能衰竭中的变化 |
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| 引用本文： | 章安源,朱伟,孙青,鹿伟,王晓虹. 降钙素基因相关肽和内皮素-1在大鼠急性肾功能衰竭中的变化[J]. 中国辐射卫生, 2008, 17(1): 10-12. DOI: 10.13491/j.cnki.issn.1004-714x.2008.01.049 |
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| 作者姓名： | 章安源 朱伟 孙青 鹿伟 王晓虹 |
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| 作者单位： | 1. 山东省千佛山医院病理科, 山东济南 250016;2. 山东省医学科学院放射医学研究所;3. 解放军总医院第一附属医院 |
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| 摘 要： | 目的 研究降钙素基因相关肽(CGRP)舒血管物质对急性肾功能衰竭(ARF)的影响,探讨CGRP和内皮素-1(ET-1)在ARF中的变化和作用。方法 运用放免法检测大鼠不同时间血浆CGRP、ET-1水平的变化,并检测大鼠的肾功指标,对其进行评估。结果 甘油所致ARF大鼠血浆CGRP水平明显降低(P<0.05);血浆ET水平明显增高(P<0.01)。结论 血浆CGRP、ET-1含量测定可以作为反映肾功能状态和分析ARF病程发展与转归的敏感指标。CGRP对ARF时的肾脏有保护功能。
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| 关 键 词： | 急性肾功能衰竭 降钙素基因相关肽 内皮素-1 放免法 |
| 文章编号： | 1004-714X（2008）01-0010-02 |
| 收稿时间： | 2007-11-16 |
| 修稿时间： | 2007-11-16 |
Changes of Calcitonin Gene-related Peptide and Endothelin-1 and Their Effects in Rats with Acute Renal Failure. |
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| ZHANG An- yuan ,ZHU Wei,SUN Qing,et al.. Changes of Calcitonin Gene-related Peptide and Endothelin-1 and Their Effects in Rats with Acute Renal Failure.[J]. Chinese Journal of Radiological Health, 2008, 17(1): 10-12. DOI: 10.13491/j.cnki.issn.1004-714x.2008.01.049 |
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| Authors: | ZHANG An- yuan ZHU Wei SUN Qing et al. |
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| Affiliation: | Shangdong Qianfoshan Hospital, Jinan 250014 China |
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| Abstract: | Objective To study the effects of CGRP and ET-1 and to evaluate their changes during ARF.Methods The levels of CGRP and ET-1 in serum were measured by radioimmunity and was evaluated the renal function.Results The level of CGRP decreased significantly (P<0.05), and the level of ET-1 increased significantly (P<0.01)in serum.Conclusion The levels of CGRP and ET-1 in serum could reflect the renal functional state and clinical course in ARF.CGRP had a protected effect on the ischemic kidney. |
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| Keywords: | ARF CGRP ET- 1 Radioimmunity |
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