脑白质病变认知障碍的危险因素研究

目的研究缺血性脑白质病变患者认知功能障碍的发病率及相关危险因素。方法收集75例脑白质病变(white matter lesions,WML)患者的人口学资料和血管危险因素,并进行认知功能评定,将病例分为认知障碍组和对照组,2组对比研究,探讨WML患者认知障碍的可能危险因素。结果 75例患者中44例(58.7%)出现了不同程度的认知功能障碍。Logistic回归分析显示WML患者发生认知功能障碍与高血压(OR 4.050,95%CI 1.309～12.526)、糖尿病(OR 3.820,95%CI 1.103～13.231)和年龄(OR 1.133,95%CI 1.023～1.255)有关。结论较高比例WML患者可出现认知功能障碍,高血压、糖尿病和老龄与认知功能障碍的发生关系密切。

Risk factors for vascular cognitive impairment due to white matter lesions

Objective To explore the incidence rate and relative risk factors of cognitive impairment due to ischemic white matter lesions(white matter lesions,WML).Methods Seventy-five patients with WML,whose detailed demographic data and vascular risk factors were collected,were classified into cognitive impairment and normal control group,demographic data and vascular risk factors were compared to explore the risk factors for cognitive impairment due to WML.Results Of the 75 patients with WML,cognitive impairment presented in 44(58.7%)patients,Logistic regressions analysis identified the presence of cognitive impairment is significantly associated with hypertension(OR 4.050,95% CI 1.309~12.526),diabetes(OR 3.820,95% CI 1.103~13.231)and age(OR 1.133,95% CI 1.023~1.255).Conclusion Our study confirms that the presence of cognitive impairment is common in WML patients,and is significantly associated with hypertension,diabetes and age.