Tumor endothelial cells express high pentraxin 3 levels |
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| Authors: | Kyoko Hida Nako Maishi Taisuke Kawamoto Kosuke Akiyama Noritaka Ohga Yasuhiro Hida Kenji Yamada Takayuki Hojo Hiroshi Kikuchi Masumi Sato Chisaho Torii Nobuo Shinohara Masanobu Shindoh |
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| Affiliation: | 1. Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan;2. Department of Vascular Biology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan;3. Department of Oral Diagnosis and Medicine, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan;4. Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan;5. Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Japan;6. Department of Dental Anesthesiology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan;7. Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan;8. Department of Oral and Maxillofacial Surgery, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan;9. Department of Oral Pathology and Biology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan |
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| Abstract: | It has been described that tumor progression has many similarities to inflammation and wound healing in terms of the signaling processes involved. Among biological responses, angiogenesis, which is necessary for tumor progression and metastasis, is a common hallmark; therefore, tumor blood vessels have been considered as important therapeutic targets in anticancer therapy. We focused on pentraxin 3 (PTX3), which is a marker of cancer‐related inflammation, but we found no reports on its expression and function in tumor blood vessels. Here we showed that PTX3 is expressed in mouse and human tumor blood vessels based on immunohistochemical analysis. We found that PTX3 is upregulated in primary mouse and human tumor endothelial cells compared to normal endothelial cells. We also showed that PTX3 plays an important role in the proliferation of the tumor endothelial cells. These results suggest that PTX3 is an important target for antiangiogenic therapy. |
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| Keywords: | angiogenesis antiangiogenic drugs cancer pentraxin 3 tumor endothelial cells |
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