尼莫地平对轻度认知损伤患者的干预治疗研究

目的 采用尼莫地平对轻度认知损伤（MCI）患者进行治疗,观察其服药后的认知功能及脑内代谢产物的变化。方法入选31例MCI患者,尼莫地平组16例口服尼莫地平30mg,3次／d,连续3个月,对照组15例。用药前后均行认知功能评定并对治疗组中5例患者分别在用药前后行海马区磁共振质子波谱检查。结果与对照组相比,尼莫地平组用药后词语即刻回忆、符号数字转换以及简易智力状态测查的成绩显著提高（P〈0．05）。结论服用尼莫地平对MCI患者的记忆力、注意力有一定改善,进而使MCI患者总体认知功能也有提高。

A nimodipine interventional study of patients with mild cognitive impairment

Objective To observe the effect of nimodipine on the cognition status and the changes of metabolites in brain tissue in the patients with mild cognitive impairment (MCI) in order to evaluate the significance of interventing MCI with medication. Methods 31 patients with MCI were selected 16 cases were in a treatment group taking nimodipine for 3 months besides taking basic internal medication and 15 cases in a control group taking only basic internal medication. Before and after treatment, multiple cognition tests were carried out in both groups and magnetic resonance spectroscopy (MRS ) in Hippocampus region was carried out in 5 patients of the treatment group. Results Verbal instant recall scores, symbol digit modalities test (SDMT) scores and mini-mental state examination (MMSE) total scores in the treatment group were improved significantly after treatment as compared with those in the control group(P<0.05). Conclusion Nimodipine can improve memory ability as well as attention ability of the patients with MCI to a certain extent and make the general cognition function improved.