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Desferrioxamine-related ocular toxicity: a case report
Authors:Sumu Simon  Paul A Athanasiov  Rajeev Jain  Grant Raymond  Jagjit S Gilhotra
Affiliation:Retinal Unit, Department of Ophthalmology and Visual Sciences, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, South Australia.
Abstract:
A 29-year-old lady receiving repeated blood transfusions for β thalassemia since childhood, presented with rapidly deteriorating symptoms of night blindness and peripheral visual field loss. She was recently commenced on high-dose intravenous desferrioxamine for reducing the systemic iron overload. Clinical and investigative findings were consistent with desferrioxamine-related pigmentary retinopathy and optic neuropathy. Recovery was partial following cessation of desferrioxamine. This report highlights the ocular side-effects of desferrioxamine mesylate and the need to be vigilant in patients on high doses of desferrioxamine.
Keywords:Desferrioxamine   ocular toxicity   optic neuropathy   pigmentary retinopathy
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