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| 188Re-碘化油-羧甲基壳聚糖-纳米微粒在荷S180肉瘤小鼠体内分布与代谢 | |
| 引用本文： | 王洪震,贾正平,郝彦明,钱荣勋,董启榕,徐又佳. 188Re-碘化油-羧甲基壳聚糖-纳米微粒在荷S180肉瘤小鼠体内分布与代谢[J]. 中国组织工程研究与临床康复, 2011, 15(51). DOI: 10.3969/j.issn.1673-8225.2011.51.024 |
| 作者姓名： | 王洪震 贾正平 郝彦明 钱荣勋 董启榕 徐又佳 |
| 作者单位： | 1. 昆山市第一人民医院,江苏省昆山市,215300 2. 苏州大学附属二院,江苏省苏州市,215000 |
| 摘 要： | 背景:188Re标记的放射性药物在体内发生 Re核索脱落也不会对人体造成严重的辐射损伤.188Re-碘化油有可能成为一种具有临床应用价值的内照射治疗肿瘤的药物.目的:研究羧甲基壳聚糖载药纳米微球的制备及在荷S180肉瘤小鼠体内分布及代谢.方法:将188Re-碘化油通过羧甲基壳聚糖纳米微球包裹,将其注射于荷S180肉瘤小鼠体内,通过 SPECT法观察188Re-碘化油-羧甲基壳聚糖-纳米微粒在荷瘤鼠中的显像.结果与结论:采用羧甲基壳聚糖-纳米微粒对188Re-碘化油标记率达(94.9±0.2)%;肝、肾是188Re-碘化油-羧甲基壳聚糖-纳米微粒的主要分布器官;骨、肌肉、小肠等脏器摄取较少,且随着时间的延长而下降;脑内未测得放射性,各比值随着时间的延长而有增加的趋势,分别在注射显像剂后6~10 h达到峰值.说明羧甲基壳聚糖-纳米微粒对188Re的包裹效果良好;188Re-碘化油-羧甲基壳聚糖-纳米微粒在正常骨、肌肉、小肠基本无摄取,但48 h浓聚于肉瘤组织内,肿瘤与脾、胃、肠、股骨、肌肉、脂肪组织放射性比值高. |
| 关 键 词： | 羧甲基壳聚糖 纳米微球 肉瘤小鼠 体内分布 代谢 |
In vivo distribution and metabolism of 188Re-iodized oil-carboxymethyl chitosan-nanoparticles in the S180 tumor-bearing mice |
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| Wang Hong-zhen,Jia Zheng-ping,Hao Yan-ming,Qian Rong-xun,Dong Qi-rong,Xu You-jia. In vivo distribution and metabolism of 188Re-iodized oil-carboxymethyl chitosan-nanoparticles in the S180 tumor-bearing mice[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(51). DOI: 10.3969/j.issn.1673-8225.2011.51.024 | |
| Authors: | Wang Hong-zhen Jia Zheng-ping Hao Yan-ming Qian Rong-xun Dong Qi-rong Xu You-jia |
| Affiliation: | Wang Hong-zhen1,Jia Zheng-ping1,Hao Yan-ming1,Qian Rong-xun1,Dong Qi-rong2,Xu You-jia2 1First People's Hospital of Kunshan,Kunshan 215300,Jiangsu Province,China,2Second Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu rovince |
| Abstract: | BACKGROUND:188Re labeled radiopharmaceuticals in body occur Re nuclear cable off which will not cause serious radiation damage of the body.188Re-iodized oil may become a kind of clinical application of drugs within the radiation treatment of cancer.OBJECTIVE:To study preparation of drug-loaded nano-carboxymethyl chitosan microspheres and in vivo distribution and metabolism in the S180 tumor-bearing mice.METHODS:188Re-lipiodol was wrapped by carboxymethyl chitosan nanoparticles,the wrapped 188Re-lipiodol was... |
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