| 猪不停跳心脏离体模型的建立 |
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| 引用本文： | 郑民,宋剑非,杨峰,张文斌. 猪不停跳心脏离体模型的建立[J]. 中国组织工程研究与临床康复, 2011, 15(53). DOI: 10.3969/j.issn.1673-8225.2011.53.028 |
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| 作者姓名： | 郑民 宋剑非 杨峰 张文斌 |
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| 作者单位： | 桂林医学院附属医院胸心外科,广西壮族自治区桂林市,541001 |
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| 基金项目： | 广西科学基金项目(桂科基0236068),供体心脏不停跳和停跳保存方法对心肌保护的对比研究~~ |
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| 摘 要： | 背景:保持供心离体跳动,可以减少供心的缺血时间,延长供心的离体保存时间.目的:建立稳定简便的猪不停跳心脏离体模型.方法:12只健康家猪随机等分为不停跳组和冷晶体灌注组.不停跳组经升主动脉建立冠状动脉灌注,经右心房进右心室建立静脉引流,经左心耳放置软管入左心室引流,建立猪的不停跳心脏离体模型.冷晶体灌注组按常规心脏移植实行心脏离体保护.结果与结论:不停跳组共施行6例猪心脏离体手术,术后2,4 h离体心脏不停跳成功率为100%(6/6),6 h离体心脏不停跳成功率为83%(5/6).与对照组相比,不停跳组丙二醛水平降低,超氧化物歧化酶活性升高(P < 0.05),心肌超微结构保持良好.说明猪的不停跳心脏离体模型成功率高,是研究离体不停跳心脏仪器的稳定可靠动物模型.
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| 关 键 词： | 心脏不停跳 离体 猪 心肌保护 心脏移植 |
Establishment of a porcine beating heart model in vitro |
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| Zheng Min,Song Jian-fei,Yang Feng,Zhang Wen-bin. Establishment of a porcine beating heart model in vitro[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(53). DOI: 10.3969/j.issn.1673-8225.2011.53.028 |
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| Authors: | Zheng Min Song Jian-fei Yang Feng Zhang Wen-bin |
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| Affiliation: | Zheng Min,Song Jian-fei,Yang Feng,Zhang Wen-bin Department of Cardiothoracic Surgery,Affiliated Hospital of Guilin Medical University,Guilin 541001,Guangxi Zhuang Autonomous Region,China |
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| Abstract: | BACKGROUND: Keeping beating of the donor heart can reduce its ischemia time and prolong its preservation time in vitro. OBJECTIVE: To establish a simple and stable model of porcine beating heart in vitro. METHODS: Twelve healthy pigs were randomly divided into beating group and cold crystalloid perfusion group. In the beating group, coronary perfusion was established through the ascending aorta, venous drainage was established through right atrium into the right ventricle, the hose was placed into the left ... |
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