中性粒细胞/淋巴细胞比值和hs-CRP与急性脑梗死的相关性

目的探讨中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、超敏C反应蛋白(hsCRP)与急性脑梗死的相关性。方法选取作者医院发病24h内入院的82例急性脑梗死患者,根据临床神经功能缺损程度评分分为轻、中、重度3组,另选取40名健康体检者为对照组,比较各组患者hs-CRP和NLR水平,分析hs-CRP、NLR与急性脑梗死患者神经功能损伤程度的相关性。结果 (1)急性脑梗死组hs-CRP、NLR水平均高于对照组(P0.05);(2)轻、中、重度脑梗死患者hs-CRP水平依次升高,组间两两比较差异有统计学意义(P0.05),中、重度脑梗死组NLR较轻度组升高(P0.05),而重度组与中度组间NLR比较差异无统计学意义(P=0.057);(3)hs-CRP、NLR水平与神经功能缺损程度均呈正相关(r=0.76,P0.05;r=0.46,P0.05),NLR与hs-CRP间呈正相关(r=0.78,P0.05)。结论 NLR、hs-CRP水平可反映急性脑梗死神经功能损伤程度,监测其水平变化有助于临床对疾病的早期评估和干预,利于改善患者预后。

The correlation between neutrophil to lymphocyte ratio,high-sensitivity C-reactive protein and acute cerebral infarction

Objective To investigate the relationship between neutrophil to lymphocyte ratio (NLR) , hypersensitive C‐reactive protein (hs‐CRP ) and neurological impairment degree in acute cerebral infarction patients. Methods Eighty‐two patients with acute cerebral infarction who were admitted into hospital within 24 hours and 40 healthy controls were selected. Patients were divided into the mild group , the moderate group and the severe group according to clinical neurological impairment score standards.NLR and hs‐CRP levels were detected in all objects 1d after admission into hospital. Levels of NLR and hs‐CRP were compared among groups.The correlation between NLR ,hs‐CRP and the neurological function impairment degree were analyzed respectively. Results (1) Compared with the healthy controls , NLR and hs‐CRP levels in the patients were significantly higher (P<0.05 , respectively) . (2) Pairwise comparison was adopted between the mild group , the moderate group and the severe group. The differences of hs‐CRP levels between the three groups were statistically significant (P<0.05 , respectively) . The NLR levels of the severe and moderate group were higher than that of the mild group (P< 0.05 ,respectively) ,while the difference between the severe group and the moderate group was not significant (P=0.057) . (3) Correlation analysis indicated that both NLR and hs‐CRP had positive correlation with the neurological function impairment degree (r=0.76 , P<0.05 ;r=0.46 , P<0.05) ,and there was a significant positive correlation between NLR and hs‐CRP (r= 0.78 , P< 0.05) . Conclusions The levels of NLR and hs‐CRP in patients with cerebral infarction can reflect neurological impairment degree , and monitoring of these two indicators is helpful for early assessment and intervention to improve the prognosis of the patients.