Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils |
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| Authors: | Ki-Yeon Yoo In Hye Kim Jeong-Hwi Cho Ji Hyeon Ahn Joon Ha Park Jae-Chul Lee Hyun-Jin Tae Dae Won Kim Jong-Dai Kim Seongkweon Hong Moo-Ho Won Il Jun Kang |
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| Affiliation: | 1. Department of Oral Anatomy,College of Dentistry and Research Institute of Oral Science,Gangneung-Wonju National University,Gangneung,Republic of Korea;2. Department of Neurobiology,School of Medicine,Kangwon National University,Chuncheon,Republic of Korea;3. Department of Biomedical Science,Research Institute of Bioscience and Biotechnology,Hallym University,Chuncheon,Republic of Korea |
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| Abstract: | In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne(CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive days followed by bilateral carotid artery occlusion to make a cerebral ischemia/reperfusion model. Then, we found that CIL extracts protected pyramidal neurons in the hippocampal CA1 region(CA1) from ischemic damage using neuronal nucleus immunohistochemistry and Fluoro-Jade B histofluorescence. Accordingly, interleukin-13 immunoreactivities in the CA1 pyramidal neurons of CIL-pretreated animals were maintained or increased after cerebral ischemia/reperfusion. These findings indicate that the pre-treatment of CIL can attenuate neuronal damage/death in the brain after cerebral ischemia/reperfusion via an anti-inflammatory approach. |
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| Keywords: | nerve regeneration transient cerebral ischemia delayed neuronal death pyramidal neurons inflammatory cytokines neural regeneration |
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