|
|||||
|
|
Molecular epidemiology of the SH (small hydrophobic) gene of human respiratory syncytial virus (HRSV), over 2 consecutive years |
|
| Authors: | Lima Hildenêr Nogueira Botosso Viviane Fongaro Oliveira Danielle Bruna Leal Campos Angélica Cristine de Almeida Leal Andrea Lima Silva Tereza Souza Bosso Patrícia Alves Ramos Moraes Claudia Trigo Pedroso Filho Claudionor Gomes da Silva Vieira Sandra Elisabete Gilio Alfredo Elias Stewien Klaus Eberhard Durigon Edison Luiz |
| Affiliation: | a Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes 1374, 05508-900 São Paulo, SP, Brazil b Instituto Butantan, Av. Vital Brazil, 1500, 05503-900 São Paulo, SP, Brazil c Hospital Universitário, Universidade de São Paulo, Av. Prof. Lineu Prestes, 2565, 05508-900 São Paulo, SP, Brazil |
| Abstract: | Human respiratory syncytial virus (HRSV) strains were isolated from nasopharyngeal aspirates collected from 965 children between 2004 and 2005, yielding 424 positive samples.We sequenced the small hydrophobic protein (SH) gene of 117 strains and compared them with other viruses identified worldwide. Phylogenetic analysis showed a low genetic variability among the isolates but allowed us to classify the viruses into different genotypes for both groups, HRSVA and HRSVB. It is also shown that the novel BA-like genotype was well segregated from the others, indicating that the mutations are not limited to the G gene. |
| Keywords: | HRSV Small hydrophobic protein Molecular epidemiology |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |