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| 川芎嗪对离体豚鼠心房的作用特点 | |
| 引用本文： | 吴芹 黄燮南. 川芎嗪对离体豚鼠心房的作用特点[J]. 遵义医学院学报, 1996, 19(1): 8-10 |
| 作者姓名： | 吴芹 黄燮南 |
| 作者单位： | 遵义医学院药理学教研室(吴芹，黄燮南，谢笑龙)，遵义医学院药理学教研室!贵阳市第五人民医院药局(陈怡) |
| 摘 要： | 本实验观察了川芎嗪（ＴＭＰ）对离体豚鼠心房的作用特点，结果表明：ＴＭＰ０．１￣１ｍｍｏｌ／Ｌ使右心房自律性和左心房的收缩幅度增高；３ｍｍｏｌ／Ｌ则使右心房自律性、左、右心房收缩幅度和左心房兴奋性降低，功能不应期略延长。ＴＭＰ抑制心肌收缩的作用被钾通道阻滞剂四丁胺（１ｍｍｏｌ／Ｌ）明显对抗。 |
| 关 键 词： | 川芎嗪 离体心房 |
The characteristics of effects of tetramethlypyrazine on isolated guinea pig atrium |
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| WU Qin,HUANG Xie-Nan,XIE Xiao-Long and CHEN Yi.. The characteristics of effects of tetramethlypyrazine on isolated guinea pig atrium[J]. Acta Academiae Medicine Zunyi, 1996, 19(1): 8-10 | |
| Authors: | WU Qin HUANG Xie-Nan XIE Xiao-Long CHEN Yi. |
| Abstract: | The cardiac effects of Tetramethylpyrazine (TMPR) were studied in iso-lated guinea pig atruim. The lower concentration of TMPR (0. 1-1mmol/L) in-creaseed the automaticity of right atrium and the contractile amplitude of left atri-um. But, the high concentration of TMPR (3 mmol/L) reduced the automaticity of right.atrium, the excitability and contractile amplitude of left atrium, and extended the functional refractory period of left atrium. The effect of TMPR deprssing my-ocardial contractibility was antagonized by K channel blocker tetrabutylammonium (TBA). |
| Keywords: | tetramethylpyrazine guinea pig isolated atrium |
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