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| 噻吩骈嘧啶二酮类化合物的合成及其强心活性 | |
| 引用本文： | 噻吩骈嘧啶二酮类化合物的合成及其强心活性[J]. 中国药科大学学报, 1998, (5): 11-15. |
| 作者姓名： | 王礼琛 刘保林 |
| 作者单位： | 中国药科大学有机化学教研室 |
| 摘 要： | 设计合成了１２个噻吩骈［３，４－ｄ］嘧啶－２，４－二酮类化合物，其结构经红外光谱、核磁共振光谱、质谱证实。初筛试验表明，大部分化合物具有强心活性，其中化合物ＴＰＤ１２的活性最好 |
| 关 键 词： | 茶碱 噻吩骈嘧啶二酮 合成 强心活性 |
Synthesis and Cardiac Activity of Thieno Pyrimidine 2,4 Dione Derivatives |
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| Synthesis and Cardiac Activity of Thieno Pyrimidine 2,4 Dione Derivatives[J]. Journal of China Pharmaceutical University, 1998, (5): 11-15. | |
| Authors: | Wang Lichen Reng Jinzhi Liu Baolin Li Jiaxuan Yuan Jing |
| Affiliation: | Wang Lichen,Reng Jinzhi,Liu Baolin,Li Jiaxuan,Yuan Jing Department of Organic Chemistry, 1Department of Pharmacology of Chinese Materia Medica,China Pharmaceutical University,Nanjing 210009 |
| Abstract: | In search of new cardiac compounds twelve derivatives of thieno pyrimidine 2,4 dione were designed and synthesized Their structures were confirmed by spectroscopic elucidation In preliminary biological testes, some of the compounds showed the varied cardiac activities The best one is compound TPD 12 |
| Keywords: | Theophylline Thieno pyrimidine 2 4 dione derivatives Synthesis Cardiac activity |
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