克拉霉素与复方玄驹胶囊序贯治疗解脲支原体感染引起的精液异常

目的探讨解脲支原体（UU）感染引起男性不育患者精液质量异常的治疗方法。方法将891例uu阳性的男性不育患者随机平均分为三组，三组治疗前精液质量比较差异无显著性，A组克拉霉素干混悬剂治疗，转阴后三个月复查精液常规；B组复方玄驹胶囊治疗三个月复查精液常规；C组克拉霉素干混悬剂治疗转阴后复方玄驹胶囊治疗三个月复查精液常规。结果A组和C组治疗后与同组治疗前比较，患者精子浓度A组：（45．14±4．361×10^6／mlvs（32．67±4．34）×10^6／ml；C组：（55．14±5．56）×10^6／mlvs（32．59±4．11）×10^6／ml、前向运动PRA组：（26．24±8．45）％vs（20．53±9．52）％；C组：（30．24±9．45）％vs（20．76±9．25）％]、正常形态率陋组：（4．85±4．78）％vs（3．42±4．68）％；C组：（5．75±4．56）％vs（3．43±4．66）％]，差异有统计学意义（A组P〈0．05、C组P〈0．01）；B组治疗后与治疗前比较，患者精子浓度（33．81±4．43）X106／mlvs（31．92±4．10）×10^6／ml]、前向运动PR（20．78±9．54）％vs（21．38±931）％]、正常形态率（3．35±4．82）％vs（3．38±4．71）％]，差异无统计学意义（P〉0．05）；C组与A组和B组治疗后精液质量比较，差异有统计学意义（P〈0．01）。结论克拉霉素干混悬剂与复方玄驹胶囊序贯治疗能有效提高解脲支原体感染引起的男性不育患者的精子浓度、前向运动PR、正常形态率。

The sequential treatment for abnormal semen quality caused by ureaplasma urealyticum infection by clarithromycin and compound Xuanju capsule

Objective To discuss the treatment method for abnormal semen quality caused by ureaplasma urealyticum （UU） infection in male infertility patients. Methods 891 cases of UU positive male infertility patients were randomly divided into three groups. The three groups before treatment showed no significant differences in semen quality. Group A was treated with clarithromycin, negative after three months of routine semen; Group B used compound Xuanju capsule in treatment of three months of routine semen; group C used clarithromycin in the treatment of negative after compound Xuanju capsule in treatment of three months of routine semen. Results Group A and C after treatment with sperm concentrationA： （45.14 ± 4.36） × 10^6/ ml vs （32.67 ± 4.34）× 10^6/ml; C： （55.14 ± 5.56）× 10^6/ml vs（32.59 ± 4.11）× 10^6/ml], progressive motility PR RA： （26.24 ±8.45）% vs （20.53 ± 9.52）%; C： （30.24 ± 9.45）% vs （20.76 ±9.25）%], normal morphology rateA ： （4.85 ±4.78）% vs （3.42± 4.68）% ; C ： （5.75± 4.56）% vs （3.43 ± 4.66）%] with the same group before treatment, the difference was statistically significant （ A：P 〈 0.05, C：P 〈 0.01 ） ; Group B patients after the treatment of sperm concentration （33.81±4.43）× 10^6/ml vs （31.92±4.10）× 10^6/ml], progressive motility PR（20.78 ± 9.54）% vs （21.38 ±9.31）%], normal morphology rate（3.35 ± 4.82）% vs （3.38 ±4.71）%] with the same group before treatment, the differences were not statistically significant （/9〉0.05）; group C and A and group B after treatment of semen quality were compared, the difference was statistically significant （P〈0.01）. Conclusion Clarithromycin combined and compound Xuanju capsule sequential therapy can effectively improve the sperm concentration, progressive motility PR, normal morphology rate in male infertility patients of UU infection.