| α-干扰素与慢性髓性白血病来源的树突状细胞 |
| |
| 引用本文： | 翁开枝,邱国强,谢晓宝. α-干扰素与慢性髓性白血病来源的树突状细胞[J]. 白血病．淋巴瘤, 2006, 15(5): 385-387 |
| |
| 作者姓名： | 翁开枝 邱国强 谢晓宝 |
| |
| 作者单位： | 213003,常州,苏州大学附属第三医院血液实验室;213003,常州,苏州大学附属第三医院血液实验室;213003,常州,苏州大学附属第三医院血液实验室 |
| |
| 摘 要： | 各种临床观察肯定了α-干扰素（IFN-α）治疗慢性髓性白血病的疗效,其可明显延长白血病的慢性期及患者生存时间。树突状细胞（DC）作为功能最强的专职抗原递呈细胞,能有效递呈白血病抗原,逆转机体对白血病抗原的耐受,启动特异抗白血病的T细胞应答。IFN-α用于诱导慢性髓性白血病来源的DC,已经取得一定成绩,用IFN-α诱导慢性髓性白血病细胞分化成为具有较强功能的"临床型"DC被寄予厚望。
|
| 关 键 词： | α-干扰素 慢性髓性白血病 树突状细胞 |
| 文章编号： | 1009-9921（2006）05-0385-03 |
| 收稿时间： | 2005-11-21 |
| 修稿时间： | 2006-02-20 |
Interferon-alpha and dendritic cells derived from chronic myeloid leukemia |
| |
| WENG Kai-zhi,QIU Guo-qiang,XIE Xiao-bao. Interferon-alpha and dendritic cells derived from chronic myeloid leukemia[J]. Journal of Leukemia & Lymphoma, 2006, 15(5): 385-387 |
| |
| Authors: | WENG Kai-zhi QIU Guo-qiang XIE Xiao-bao |
| |
| Affiliation: | Laboratory of Hematalogy, the Third Hospital of Suzhou University, Changzhou 213003, China |
| |
| Abstract: | Interferon-alpha,an important immunoregulatory cytokine,has been widely used in treating chronic myeloid leukemia and showed evident effect through many clinic observations.It can obviously prolong chronic period and survival time of the patients of chronic myeloid leukemia.Dendritic cells,the best function of specialized antigen-presenting cells,can not only efficiently present leukemia-antigen to T cells and reverse the tolerance of organism for leukemia-antigen,but also initiate T cells and maintain specific immune response for leukemia.Interferon-alpha,which has been used in the induction of CML-derived DC,has acquired some achievements.In the presence of interferon-alpha,the CML-cells are induced into "clinic" DC with superior function,which has a promising potentiality.< |
| |
| Keywords: | Interferon-alpha Dendritic cells Chronic myeloid leukemia |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《白血病．淋巴瘤》浏览原始摘要信息 |
|
点击此处可从《白血病．淋巴瘤》下载免费的PDF全文 |
|
