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The emergence of concurrent HIV-1/AIDS and visceral leishmaniasis in Northeast Brazil |
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| Authors: | Nascimento E T Moura M L N Queiroz J W Barroso A W Araujo A F Rego E F Wilson M E Pearson R D Jeronimo S M |
| Affiliation: | a Department of Infectious Disease, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil b Health Post-Graduate Program, Health Sciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil c Department of Biochemistry, Biosciences Center, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil d Hospital Giselda Trigueiro, Secretaria Estadual de Saúde, Natal, RN, Brazil e Departments of Internal Medicine, Microbiology and Epidemiology, University of Iowa and the VA Medical Center, Iowa City, IA, USA f Departments of Medicine and Pathology, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA g Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais, Natal, RN, Brazil |
| Abstract: | HIV has become increasingly prevalent in the Northeast region of Brazil where Leishmania infantum chagasi is endemic, and concurrent AIDS and visceral leishmaniasis (VL) has emerged. In this study, persons with HIV/AIDS and VL (n = 17) had a mean age of 37.3 years (range 29-53 years) compared with 12.5 years (1-80 years) for persons with VL alone (n = 2836). Males accounted for 88% of cases with concurrent VL and AIDS and 65% of those with VL alone. The mean CD4 count and antileishmanial antibody titre were lower and recurrence of VL and death were more likely with co-infection. Considering the prevalences of L.i. chagasi and HIV in the region, this may herald the emergence of an important public health problem. |
| Keywords: | Visceral leishmaniasis HIV AIDS Leishmania chagasi Co-infection Brazil |
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