肝病患者蛇毒凝血试验变化的临床研究

本文采用中国蝰蛇毒试剂(Chinese Russell Viper Venom Reagont;CRVVR)及中国蕲蛇毒试剂(Chinese Agkistrodon Acutus enzyme Reagent;CAAE)对50例肝硬化失代偿期病人,25例肝肿瘤病人的凝血象进行了检测,并将RVVCT、RVVRT、AT与传统肝功能指标及凝血试验进行对比。证实蛇毒凝血试验时间在肝硬化失代偿期及肝肿瘤时明显长于正常对照组(P<0.01),异常检出率高于传统凝血试验,与肝功受损程度呈正相关。肝癌病人中,AT延长的阳性率高于AFP。说明蛇毒凝血试验上脏损害程度及诊断肝癌具有一定的意义。

Clinical study of venom reagent coagulation detection in patients with liver diseses

Chinese Russel viper venom reagent(CRVV) and Chinese agkistrodon acutus enzyme reagent(CAAE) were used to detect the coagulation changes in 50 patients with decompensation cirrhosis and 25 cases with maling-nant hepatic tumors. And comparison between the venom reagent coagulation (VRC) tests (suchas RVVCT, RVVRT and AT) and traditional hepar function assay,conventional coagulation tests(CCT) was made to further determine the diagnostic value of VRC tests in hepatic disorders. The results showed that all kinds of VRC time were obviously prolonged in observation patients,compared to controls(P< 0. 01); the abnormal detective rates of RVVCT, RVVRT and AT were much higher than those of CCT and positively correlative with the damage degree of liver function. It was also observed that the positive rate of AT prolongation was higher than that of AFP in patients with hepatoma. These results suggest that VRC tests are useful for evaluating the severity of hepatic lesion and significant for diagnosing the primary hepatocellular carcinoma.