米非司酮对人蜕膜中雌激素及孕酮受体的影响 |
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引用本文: | 朱建宝 施文良. 米非司酮对人蜕膜中雌激素及孕酮受体的影响[J]. 生殖医学杂志, 1998, 7(2): 101-104 |
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作者姓名: | 朱建宝 施文良 |
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作者单位: | 淮南矿业学院医学分院,国家计划生育委员会科学技术研究所,河南计划生育研究所 |
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基金项目: | 世界卫生组织人类生殖特别规划处资助 |
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摘 要: | 本研究观察了服用米非司酮后人蜕膜中雌激素受体(ER)和孕酮受体(PR)的变化。60名孕6~7周的妇女,被随机分为3组。在手术终止妊娠前的12和24小时两组中,分别一次性口服米非司酮200mg,对照组服用安慰剂。服用米非司酮后,蜕膜中ER和PR的免疫组织化学染色反应与对照组比较增强了。卡方分析表明,服用米非司酮后,ER阳性标本的数量明显增加
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关 键 词: | 米非司酮 受体.雌激素 受体.孕酮 蜕膜 |
Effect of mifepristone on content of estrogen and progesterone receptors in human decidua |
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Abstract: | bjectives:To examine mifepristone action on decidual estrogen receptor(ER) and Progesterone recptor(PR).Design: Controlled study.Setting: Normal human volunteers in an academic research laboratory.Methods: Immunocytochemical reactions of PR and ER in decidua after mifepristone treatment were compared with the control subjects.Results: Mifepristone treatment increased PR and ER staining in vessel and stroma of decidua.Chi squared analysis indicated a significant increase in the number of ER positive samples after mifepristone treatment.Conclusion:The decidua was the primary target site of mifepristone.The receptor status changes under effects of antiprogestin. |
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Keywords: | Mifepristone Receptor estrogen Receptor progesterone Decidua |
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