CyclinD1、Cdk4在子宫内膜癌中的表达与意义

目的探讨CyclinD1、Cdk4在子宫内膜癌中的表达与意义。方法应用免疫组织化学,检测20例正常子宫内膜及20例不典型增生子宫内膜和40例子宫内膜癌中的CyclinD1与Cdk4蛋白的表达情况。结果 CyclinD1与Cdk4的阳性表达在正常子宫内膜、不典型增生子宫内膜和子宫内膜癌中依次增加,组间差异具有统计学意义（P〈0.05）,与子宫内膜癌的分化程度,Dukes分期及淋巴结转移呈正相关关系（P〈0.05）。结论 CyclinD1与Cdk4蛋白的过度表达可能在子宫内膜癌的发生、发展、浸润及转移中起重要作用,对判断子宫内膜癌的恶性程度具有一定的临床意义,还可能作为一种有价值的肿瘤标志物。

CyclinD1 and Cdk 4 Proteins Expression in Endometrial Carcinoma and its significance

Objective To study the expression of CyclinDland Cdk 4 proteins in endometrial carcinoma and its significance. Methods The expression of CyclinD1 and Cdk 4 proteins were tested by S-P immuno- histochemistry on tissues of normal endometrium （20 cases）, atypical endometrial hyperplasia （20 cases） and endometrial carcinoma （40 cases）. Results The positive expression of CyclinD1 and Cdk 4 in normal cndome- trial atypical endometrial hyperplasia and endometrial cancer in turn increase. A statistically significant differ- ence between groups （P 〈 0. 05 ） , And the differentiation of endometrial carcinoma, Dukes staging and lymph node metastasis were positively related （ P 〈 0.05 ）. Conclusion CyclinD1, Cdk 4 and excessive protein expression may be in endometrial cancer occurrence, development, invasion and metastasis plays an important role, the judgment of the endometrial carcinoma malignant degree has a certain clinical significance, but also may be as a valuable tumor markers.