肿瘤标志物联合检测对肺癌的诊断价值

目的 探讨血浆肿瘤型M2丙酮酸激酶(TuM2-PK)、神经元特异烯醇化酶(NSE)和细胞角蛋白19(CYFRA21-1)联合测定对肺癌诊断的临床意义.方法 用酶联免疫吸附试验(ELISA)法分别检测90例肺癌患者,90例良性肺部疾病和100名健康人血中的TuM2-PK、NSE和CYFRA21-1的浓度.结果 肺癌组3种指标水平均明显高于良性肺疾病组和健康对照组,差异有统计学意义(P＜0.01);TuM2-PK诊断肺癌的敏感度为68.9%,特异度为91%;TuM2-PK和NSE联合检测肺癌的阳性率最高为81%.结论 TuM2-PK可作为一种新肺癌标志物应用,TuM2-PK和NSE联合检测可以提高对肺癌的阳性诊断.

The diagnostic values of the tumor markers for lung cancer

Objective To evaluate the diagnostic values of TuM2-PK,NSE and cYFRA21-1 tumor marker for lung cancer.Methods The concentration of three nlarkers in plasma was detected by ELISA in 90 lung cancer patients.90 benign lung djsease patients and 100 healthy people.Results The concentration of TuM2-PK.NSE and CYFRA21-1 was significantlv higher in lung cancer than that in benign lung diseaSe and health controls(P＜0.01,respectively).The diagnostic sensitivity and specificity of tumor M2-PK was 68.9% and 91% respectively.The combined sensitivity of TuM2-PK+NSE(81%)for lung cancer diagnosis was higher than that of single itern or the other combination(TuM2-PK+CYFRA211).Conclusion TuM2-PK can be used in diagnosis of lung cancer.The combined detection of TuM2-PK+NSE call increase significantly the sensitivity.