槐果碱和氧化槐果碱的药动学研究进展

槐果碱和氧化槐果碱属苦参碱类生物碱。苦参碱类生物碱具有广泛的生物活性,如保护心、肝、肺、肾、脑、血管作用,对心脏有正性肌力、负性频率、抗心律失常作用,还有升高白细胞、平喘、抗溃疡、抗肝纤维化以及镇静、催眠、镇痛等中枢神经药理作用,也具有抗肿瘤、免疫调节、抗菌、抗病毒、抗炎等药理作用。文中综述槐果碱和氧化槐果碱的药动学参数及其体内过程文献,并对其药动学的研究进展做了分析,为合理用药提供参考。

Research Advances in Pharmacokinetics of Sophocarpine and Oxysophocarpine

Sophocarpine and oxysophocarpine are matrine-type alkaloids.Matrine-type alkaloids have a widespread bioactivities,including protection of heart,liver,lung,kidney,brain and blood vessel,and the effects of positive inotropism,negative chronotropism and antiarrhythmia on heart,as well as promoting leukocytes,antiasthma,antiulcer,anti-fibrogenesis in liver,and central suppression of sedation,hypnogenesis,analgesia,and antitumor,immunoregulation,anti-bacteria,anti-virus and anti-inflammation.The literatures of the pharmacokinetic parameters and process in body of sophocarpine and oxysophocarpine were reviewed,and their research advances on pharmacokinetics were analyzed,so as to provide a reference for rational usage of drugs.