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Effect of tube feeding on hippocampal-dependent memory in SAMP1 mice
Affiliation:1. The Center for Metabolism and Obesity Research, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA;2. Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA;3. Department of Neurology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA;4. Department of Biological Chemistry, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA;5. Departamento de Química Biológica, Facultad de Ciencias Químicas, CIQUIBIC-CONICET, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina;6. Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea
Abstract:
This study examined the effect of tube feeding on hippocampal Fos induction and spatial performance in a water maze task in senescenceaccelerated mice (SAMP1). Tube feeding accelerated the age-related decline in spatial memory and decreased Fos induction in the hippocampal CA1 region in aged SAMP1 mice. The results suggest that tube feeding in aged SAMP1 mice reduces input activity in the hippocampus, thereby leading to senile memory deficits.
Keywords:Fos  Hippocampus  SAMP1  Spatial memory  Tube feeding
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