| 联合检测D2-40、calretinin及HBME-1在浆膜腔积液细胞学鉴别诊断中的意义 |
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| 引用本文： | 陈颖,石园,孙路得,谢红仙,宿杰·阿克苏,周燕南,谭云山.联合检测D2-40、calretinin及HBME-1在浆膜腔积液细胞学鉴别诊断中的意义[J].临床与实验病理学杂志,2008,24(3). |
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| 作者姓名： | 陈颖 石园 孙路得 谢红仙 宿杰·阿克苏 周燕南 谭云山 |
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| 作者单位： | 复旦大学附属中山医院病理科,上海,200032 |
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| 摘 要： | 目的 观察D2-40、calretinin及HBME-1在浆膜腔积液间皮和转移性癌细胞中的表达,评价其用于鉴别诊断的价值.方法 用细胞块技术对87例浆膜腔积液标本进行免疫组化检测,观察D2-40、calretinin和HBME-1在癌细胞和间皮细胞中的表达.结果 D2-40、calretinin和HBME-1标记间皮细胞的敏感度分别为48.1%、81.0%、77.2%,特异度分别为90.2%、69.5%、61.0%.三者联合的敏感度和特异度分别为70.9%和81.7%.三者标记卵巢癌腹水间皮细胞的特异性都不高.结论 D2-40、calretinin和HBME-1合用可辅助鉴别诊断转移性癌与间皮.
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| 关 键 词： | 浆膜腔积液 免疫组织化学 鉴别诊断 |
Combined detection of D2-40,calretinin and HBME-1 in differential diagnosis of body cavity effusion cytology |
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| CHEN Ying,SHI Yuan,SUN Lu-de,XIE Hong-xian,SU Jie-A Ke-su,ZHOU Yan-nan,TAN Yun-shan.Combined detection of D2-40,calretinin and HBME-1 in differential diagnosis of body cavity effusion cytology[J].Chinese Journal of Clinical and Experimental Pathology,2008,24(3). |
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| Authors: | CHEN Ying SHI Yuan SUN Lu-de XIE Hong-xian SU Jie-A Ke-su ZHOU Yan-nan TAN Yun-shan |
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| Institution: | Department of Pathology;Fudan University Cancer Hospital;Shanghai 200032;China |
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| Abstract: | Purpose To evaluate the value of D2-40,calretinin and HBME-1 in identifying the mesothelial cells in body cavity effusions.Methods 87 effusion specimens were assessed by immunohistochemical analysis in cell blocks.Results The sensitivity rates of D2-40,calretinin and HBME-1 were 48.1%,81.0% and 77.2%,respectively.The specificity rates were 90.2%,69.5%,61.0%.And the combined sensitivity and specificity were 70.9% and 81.7%,respectively.The specificity of all the three markers in identifying the mesothelial c... |
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| Keywords: | D2-40 calretinin HBME-1 |
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