3种方案治疗外阴阴道念珠菌病305例疗效观察

目的:观察并评价3种方案治疗外阴阴道念珠菌病的疗效。方法:采用随机对照研究方法,将外阴阴道念珠菌病患者随机分组,A组(100例):顿服氟康唑150mg,同时0.5g/L碘附液擦拭阴道外阴后,阴道内喷洒制霉素粉(制霉素片与葡萄糖粉按1:2.5制成粉末),连用7d;B组(100例):0.5g/L碘附液擦拭阴道外阴后,阴道内喷洒制霉素粉,连用7d;C组(105例):顿服氟康唑150mg,同时每晚阴道放置复方莪术油栓1枚,连用7d。观察3组疗效及副反应。结果:A、B两组临床症状体征很快改善,停药7～14d、1个月和2个月复诊,A组临床有效率分别为95.00%、94.00%、93.00%,真菌转阴率分别为98.00%、95.00%、94.00%;B组临床有效率分别为94.00%、82.00%、81.00%,真菌转阴率分别为97.00%、90.00%、82.00%;C组临床有效率分别为94.29%、91.42%、90.48%,真菌转阴率分别为95.24%、94.29%、91.43%。停药1、2个月复诊B组的临床有效率较低,与A组、C组比较差异有统计学意义(P<0.05)。结论:3种方案治疗外阴阴道念珠菌病均有效;患者自觉症状改善情况在医院用药优于自己用药;阴道用药联合口服用药远期临床有效率高于单纯阴道用药。

Effect of Three Regimens on Vulvovaginal Candidiasis in 305 Women

Objective： To observe and evaluate the curative effectiveness of three regimens on vulvovaginal candidiasis （VVC）. Methods ： A random control clinical trial was conducted. And 305 patients with VVC were divided into three groups. In group A, 100 women were given 150mg of fluconazol orally, and their walls of the vagina were scrubbed with the iodophor solution （0.5g/L） and sprayed with the nysfungin powder （1 ： 2.5 of the ratio of nysfungin to glucose） for 7 consecutive days. In group B, the vaginal walls of 100 women were scrubbed with the iodophor solution （0.5g/L） and sprayed with the nysfungin powder for 7 consecutive days. In group C, 105 women were given 150mg of fluconazol orally and compound zedoary turmeric oil suppositories vaginally for 7 consecutive days. The therapeutic effects and side effects were evaluated. Results： The clinical symptoms and signs of women in group A and group B were quickly improved. At 7 to 14 days and 1 and 2 month after discontinuance of treatment, the effective rate were 95.00%, 94.00% and 93.00% respectively, and 98.00% , 95. 00% and 94.00% of the women had negative fungal cultivation in group A ; the effective rate were 94.00% , 82.00% and 81.00% respectively, and 97.00% , 90.00% and 82.00% of the women had negative fungal cultivation in group B;the effective rate were 94.29% , 91.42% and 90.48% respectively, and 95.24% , 94.29% and 91.43% of the women had nega- tive fungal euhivation in group C. One and 2 months after discontinuance of treatment, the clinical effective rate of group B was lower than those of group A and group C, showing the significant differences （ P 〈 0.05 ）. Conclusion ： The three regimens are effective for treatment of VVC. The improvement of symptoms and signs of women who are treated in the hospital is superior to those treated themselves. The long - term curative effectiveness of vaginal medication combined with oral medication is better than that of vaginal medication alone.