酪蛋白磷酸肽-无定型磷酸钙凝胶治疗釉质脱矿效果的系统评价

目的 对有关酪蛋白磷酸肽（CPP）-无定形磷酸钙（ACP）凝胶对于釉质脱矿治疗的随机对照试验（RCT）进行系统评价，评价其治疗的效果。方法 依照Cochrane系统评价员手册（5.1.0版本）指导进行分析，包含检索策略、纳入排除标准、数据提取及质量评价。通过计算机检索PubMed、Embase、Cochrane Library、中国知网（CNKI）、万方、维普（VIP）数据库，查找有关CPP-ACP的RCT，检索时间截至2016年9月。由2位研究者独立根据纳入与排除标准进行文献筛选、资料提取和质量评价后，对纳入研究进行系统评价。结果 共纳入12个RCT，各文献中的实验设计、评价标准差异较大无法进行定量分析。结论 尚无有力证据表明，CPP-ACP比常规含氟制剂存在优越性；但纳入研究数量、随访时间、设计存在局限性，且样本量较小，仍需更多高质量、长时间随访、大样本的RCT以进一步验证。

Remineralization effect of casein phosphopeptide-amorphous calcium phosphate for enamel demineralization: a system review

Objective This study aims to assess the remineralization effect of casein phosphopeptide (CPP)-amorphous calcium phosphate (ACP) on enamel demineralization by performing system review of randomized controlled trials (RCT) involving the treatment of enamel demineralization with CPP-ACP.Methods The study was developed based on the Cochrane handbook for systematic reviews of interventions (Version 5.1.0) and included the following: search strategy, selection criteria, data extraction, and risk of bias assessment. We searched electronic databases such as PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP up to September 2016. RCT of treating enamel demineralization with CPP-ACP were included. Data extraction and domain-based risk of bias assessment were independently performed by two reviewers.Results Twelve RCTs were included. Because of the difference of experimental design and evaluation standards, the quantitative analysis can not be carried out.Conclusion There is no strong evidence that CPP-ACP is superior to con-ventional fluoride formulations in enamel remineralization. However, due to the limitations of sample size, follow-up time and study design, more high quality and large-sample RCT are needed to further verify the evidence.