多原发恶性肿瘤的病理诊断和免疫组织化学研究

本文报道62例多原发恶性肿瘤(MPMN)的免疫组织化学在病理诊断中的意义,尤其是51例发生在同一系统、同一器官或对称性器官,且组织结构相似的MPMN,颇难定原发或继发。通过免疫组织化学(CEA、HCG和K_(12))研究发现:MPMN的不同癌灶中,3种免疫组化染色常不相同。而对照组中,原发灶和继发灶两者反应基本一致。研究结果提示,MPMN灶可能具有各自的代谢和功能特性。应用免疫组化方法可能有助于与继发性癌瘤相鉴别。

Role of Immunohistochemical Technique in Pathological Diagnosis of Multiple Primary Malignant Neoplasm

Significance of immunohistochemistry in pathologic diagnosis of 62 patients with multiple primary malignant neoplasm (MPMN) is studied. It must be pointed out that there are 51 MPMN occurring in the same anatomical system, or in the same organ, or in the bilateral organs with similar histostructure. By virtue of immunohistochemistry (CEA, hCG and keratin 12), it has been found that in different foci with MPMN the three immunohistochemical staining reactions are usually different. In the control group, immunohistochemical staining reactions of primary and secondary tumors are basically identical. The results show that foci with MPMN have distinct metabolic and functional characters. The immunohistochemical method may be helpful in distinguishing MPMN from secondary cancers.