笑气镇静系统与咪达唑仑口服镇静在智障儿童患者牙科治疗中的应用

目的:探讨笑气镇静系统与咪达唑仑口服镇静在智障儿童患者牙科治疗中的临床效果。方法:选取67例对口腔诊疗不配合的智障儿童患者,在门诊环境下实施笑气镇静（笑气浓度为35%~50%）和咪达唑仑口服镇静辅助诊疗（给药剂量为0.50~0.75 mg/kg）,记录各项评价指标,并对治疗效果和安全性进行比较。应用SPSSl3.0软件对2组的治疗成功率、不良反应发生率等行χ²检验。结果:2组治疗总成功率为70% ( 47/67) , 笑气镇静组的成功率为67%（26/39）,咪达唑仑口服镇静组的成功率为75%（21/28）。总不良反应发生率为13%(9/67) ,笑气镇静组不良反应发生率为5%(2/39),显著低于咪达唑仑口服镇静组(7/28,25%,P<0.05)。结论:笑气镇静系统与咪达唑仑口服镇静在智障儿童患者牙科治疗中均有较好的临床效果。笑气镇静系统的成功率稍低于咪达唑仑口服镇静者,但其不良反应明显少于后者。

Evaluation of N2O inhalation and oral midazolam conscious sedation in pediatric dentistry of children with intellectual disability

PURPOSE: To evaluate the effect of N₂O inhalation and oral midazolam sedation on uncooperative patients with intellectual disability in pediatric dentistry. METHODS: N₂O inhalation(35%-50%) and oral midazolam conscious sedation(dosages range: 0.50-0.75 mg/kg) were applied to 67 uncooperative pediatric patients with intellectual disability in outpatient department. The patients were divided into 2 groups: group A(N₂O inhalation conscious sedation)and group B(oral midazolam conscious sedation).Treatment results and safety were statistically analyzed by Chi-square test with SPSSl3.0 software package. RESULTS: The mean success rate was 70%. The success rate in group B (75%) was higher than group A (67%). The overall incidence of adverse reactions was 13%(9/67). The adverse reaction rate in group B (25%) was significantly higher than group A(5%, P<0.05). CONCLUSIONS: N₂O inhalation and oral midazolam conscious sedation are effective and safe in pediatric dental uncooperative patients with intellectual disability .