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MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer |
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| Authors: | Yu-zhou Wang Kun-peng Wu Ai-bing Wu Zhi-cheng Yang Jin-mei Li Yan-li Mo Meng Xu Bin Wu Zhi-xiong Yang |
| Affiliation: | 1. Cancer Center, Affiliated Hospital of Guangdong Medical College, No. 57 People’s Avenue South, Zhanjiang, 524002, Guangdong, People’s Republic of China 4. Cancer Center, Heyuan People’s Hospital, No. 733 Wenxiang Road, Heyuan, 517000, Guangdong, People’s Republic of China 2. Department of Oncology, The First Affiliated Hospital, Jinan University, No. 613 Huangpu Road West, Guangzhou, 510630, Guangdong, People’s Republic of China 3. Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical College, No. 57 People’s Avenue South, Zhanjiang, 524002, Guangdong, People’s Republic of China |
| Abstract: | Matrix metalloproteinase-14 (MMP-14) has been demonstrated to play an important role in tumor progression. The aim of this study was to analyze the correlation between MMP-14 expression and clinicopathologic features and its prognostic significance in non-small cell lung cancer (NSCLC). Immunohistochemical staining for MMP-14 protein was performed in 104 patients with NSCLC. High levels of MMP-14 protein were positively correlated with the status of clinical stage (I–II vs. III–IV; P?P?P?=?0.014), and differentiated degree (high vs. low or undifferentiated; P?=?0.001). The patients with higher MMP-14 expression of protein had shorter survival time than patients with low MMP-14 expression. Multivariate analysis indicated that the level of MMP-14 expression was an independent prognostic indicator (P?NSCLC. In conclusion, MMP-14 is a potential unfavorable prognostic factor for patients with NSCLC. |
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