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| 灵丹心宝胶囊对大鼠实验性心肌缺血的保护作用 | |
| 引用本文： | 武彩霞,苏存胜. 灵丹心宝胶囊对大鼠实验性心肌缺血的保护作用[J]. 山东医学高等专科学校学报, 2006, 28(5): 341-344 |
| 作者姓名： | 武彩霞 苏存胜 |
| 作者单位： | 山东医学高等专科学校,山东临沂,276002;山东医学高等专科学校,山东临沂,276002 |
| 基金项目： | 山东省临沂市科技发展基金 |
| 摘 要： | 目的观察灵丹心宝胶囊对大鼠实验性心肌梗死的保护作用。方法通过结扎大鼠冠状动脉左前降支(LAD)建立心肌梗死再灌注模型,观察灵丹心宝胶囊的作用。结果灵丹心宝胶囊分别以100、200mg/kg灌胃7d,均能降低急性心肌梗死大鼠心电图ST段的抬高,对心肌梗死30min、再灌注120min的大鼠可明显缩小梗死面积,降低血清肌酸激酶(CK)、乳酸脱氢酶(LDH)活性及脂质过氧化物丙二醛(MDA)含量,提高超氧化物歧化酶(SOD)活性。结论灵丹心宝胶囊对急性心肌缺血具有明显保护作用,可能与其增强抗氧化酶活性,减少自由基对心肌的氧化损伤有关。 |
| 关 键 词： | 灵丹心宝胶囊 心肌缺血 大鼠 |
| 文章编号： | 1001-5426（2006）05-0341-04 |
| 收稿时间： | 2006-05-27 |
| 修稿时间： | 2006-05-27 |
PROTECTIVE EFFECT OF LINGDANXINBAO CAPSULES ON EXPERIMENTAL MYOCARDIAL INFARCTION IN RATS |
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| WU Cai-xia,SU Cun-sheng. PROTECTIVE EFFECT OF LINGDANXINBAO CAPSULES ON EXPERIMENTAL MYOCARDIAL INFARCTION IN RATS[J]. Journal of Shandong Medical College, 2006, 28(5): 341-344 | |
| Authors: | WU Cai-xia SU Cun-sheng |
| Affiliation: | Shandong Medical College, Linyi, China 276002 |
| Abstract: | Objective To study the protective effect of Lingdanxinbao capsules on experimental myocardial infarction in rats.Methods The effects of lingdanxinbao capsules were determined in rat models with acute myocardial infarction induced by ligating the left anterior descending coronary artery.Results In rats treated by Lingdan Xinbao capsules(in a dosage of 100mg or 200mg/kg/d for 7 days),the sizes of acute myocardial infarction were significantly reduced,the serum creatine phosphokinase CK,lactatedehydrogenase LDH activities,and the level of serum lipidperoxidation(LPO) declined,while superoxide dismutase SOD activities were increased significantly.Conclusion Lingdanxinbao capsule has protective effect on myocardial ischemia probably by improving free radicals metabolism and myocardial metabolism.Therefore,Lingdanxinbao capsule is an effective drug for treatment of myocardial ischemia. |
| Keywords: | Lingdan Xinbao capsules Experimental myocardial infarction Rats |
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