脑梗死患者血清胆红素含量与颅内动脉狭窄的相关性研究

目的：采用 DSA 观察脑梗死患者颅内动脉狭窄情况，深入分析血清胆红素含量与与患者颅内动脉狭窄的相关性。方法纳入合格的脑梗死患者200例。对照组为无狭窄或轻度狭窄患者，例数为100例。根据颅内动脉有无狭窄分成两组。同时进行狭窄程度的亚组分析。比较不同组间及其亚组内的血清胆红素含量的差异与变化。对相关危险因素进行回归分析。结果狭窄组和对照组间总胆红素 STB、间接总胆红素 SIB 均有统计学意义（P ＜0．05）。狭窄组的总胆红素 STB、间接总胆红素 SIB 均显著低于对照组。而且重度狭窄及闭塞组的总胆红素 STB、间接总胆红素 SIB 均显著低于中度狭窄组。经多因素回归分析发现，血清胆红素、高血压、糖尿病与颅内动脉狭窄相关。结论血清胆红素含量偏低有可能是脑梗死的重要危险因素，对颅内动脉粥样硬化性狭窄发生具有相关性。

The study of the correlation between the serum bilirubin level and the intracranial artery stenosis of the patients with cere-bral infarction

Objective To analyze the correlation between the serum bilirubin level and the intracranial artery steno-sis of the patients with cerebral infarction by using DSA to observe the intracranial artery stenosis of the patients with cerebral infarction.Methods 200 patients with cerebral infarction were included as qualified cases.100 patients with mild stenosis or without stenosis were included into the control group.The research objects were divided into two groups according to whether there was the intracranial artery stenosis or not.At the same time,the subgroup analysis was employed to the degrees of stenosis.The differences and changes of the serum bilirubin levels in the different groups and subgroups were compared.The regression analysis on the related risk factors was employed.Results There were statistically significant differences of the total bilirubin SIB,the indirect bilirubin STB between the stenosis group and the control group（P 〈0.05）.The total bilirubin SIB and the indirect bilirubin STB of the stenosis group were sig-nificantly lower than those of the control group.The total bilirubin SIB and the indirect bilirubin STB of the severe ste-nosis and the occlusion group were significantly lower than those of the moderate stenosis group.Multivariate regres-sion analysis showed that serum bilirubin,hypertension,diabetes related to intracranial artery stenosis.Conclusion A lower serum bilirubin level may be an important risk factor of cerebral infarction and correlate with the occurrence of in-tracranial atherosclerotic stenosis.