Correlation between pancreatic mast cells and the low grade inflammation in adipose tissue of experimental prediabetes |
| |
| Authors: | Ahmed A.M. Abdel-Hamid Alaa El-Din L. Firgany |
| |
| Affiliation: | 1. Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt;2. Department of Basic Medical Science, Horus University, Egypt |
| |
| Abstract: | ![]()
The role of mast cells (MCs) in prediabetes (Pre-DM) is not clearly elucidated. In the current study rats (n?=?22 each) were divided equally into; control and Pre-DM (received high fat diet, HFD) groups. Samples from pancreas as well as from visceral adipose tissue (VAT) were studied for the consequent changes.We detected a significantly increased mast cell count (MCC) in the pancreas of Pre-DM compared to that of control. Frequent degranulation of MC granules was observed in Pre-DM. VAT of the Pre-DM had significantly increased (p?+) and mast cells (tryptase+) compared to that of the control. A significant increase (p?
|
| |
| Keywords: | Mast cells Prediabetes Insulin resistance β-cells Islets neogenesis Tryptase Macrophages Adipose tissue |
| 本文献已被 ScienceDirect 等数据库收录！ |
