| 胃癌中E2F-1的表达及其临床意义 |
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| 引用本文： | 夏可义,肖强,陆云飞,廖清华,黄源,林坚. 胃癌中E2F-1的表达及其临床意义[J]. 中国肿瘤临床与康复, 2005, 12(2): 124-126 |
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| 作者姓名： | 夏可义 肖强 陆云飞 廖清华 黄源 林坚 |
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| 作者单位： | 1. 广西中医学院第一附属医院普外科,南宁,530023
2. 广西医科大学第一附属医院胃肠腺体外科 |
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| 摘 要： | 目的探讨胃癌中E2F-1的表达及其临床意义.方法采用免疫组化技术对49例人原发性胃癌癌组织与癌旁正常黏膜中E2F-1的表达进行检测,通过统计学方法分析其表达情况以及与肿瘤分期、病理分型、淋巴结转移、侵袭深度之间的相互关系.结果 E2F-1在癌组织与癌旁正常黏膜中的阳性表达率分别为79.6%(39/49)和26.5%(13/49),差异有显著性(P<0.001).癌组织、癌旁正常黏膜中E2F-1的表达在不同的临床病理特征之间差异无显著性(P>0.05).结论胃癌中E2F-1超表达和反常表达与胃癌的发生有关.
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| 关 键 词： | 胃肿瘤 免疫组织化学 |
| 文章编号： | 1005-8664(2005)02-0124-03 |
| 修稿时间： | 2004-04-10 |
Expression and clinical significance of E2F-1 in human gastric carcinomas |
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| XIA Ke-yi,XIAO Qiang,LU Yun-fei,et al. Expression and clinical significance of E2F-1 in human gastric carcinomas[J]. Chinese Journal of Clinical Oncology and Rehabilitation, 2005, 12(2): 124-126 |
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| Authors: | XIA Ke-yi XIAO Qiang LU Yun-fei et al |
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| Abstract: | Objective To study the expression and clinical significance of E2F-1 in human primary gastric carcinomas.Methods Immunohistochemistry was used to detect the expression of E2F-1 in the cancer tissues and the surrounding normal mucosa in 49 cases of human primary gastric carcinomas.Statistics was used to analyze the data.Results The positive expression rate of E2F-1 in cancer tissues was 79.6%(39/49),while the postive expression rate of E2F-1 in the surrounding normal mucosa was 26.5%(13/49),with significant difference between cancer tissues and normal mucosa (P<0.001). The expression of E2F-1 in cancer tissues was not correlated with the tumor stage,pathological type,lymph node metastasis and the depth of invasion.Conclusion The results suggest that E2F-1 is over expressed in gastric carcinomas,and anomalous expression of E2F-1 may be related to the gastric tumorigenesis and progression. |
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| Keywords: | E2F-1 |
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