| 烟酸缓释骨架片的制备及体外释放度考察 |
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| 引用本文： | 王立青,江荣高,何仲贵. 烟酸缓释骨架片的制备及体外释放度考察[J]. 天津药学, 2004, 16(5): 2-4 |
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| 作者姓名： | 王立青 江荣高 何仲贵 |
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| 作者单位： | 1. 天津药物研究院,天津,300193
2. 沈阳药科大学药学院,沈阳,110016 |
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| 摘 要： | 目的 :制备烟酸缓释骨架片并考察其体外释放度。方法 :以国外上市 Niaspan R○ 作为对照 ,考察了 4种型号的羟丙基甲基纤维素 (HPMC)对释放性能的影响 ,并比较了缓释片在水、0 .1mol/ L 盐酸及 p H6 .8磷酸盐缓冲液三种介质中的释放度。结果 :用 Higuchi方程拟合发现 ,自制片和对照片均具有典型的缓释性能 ,而且自制片和对照片的释放度没有差别。结论 :自制的烟酸缓释骨架片工艺简单易行 ,释放度亦符合要求。
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| 关 键 词： | 烟酸 缓释骨架片 制备 体外释放 |
| 文章编号： | 1006-5687(2004)05-0002-03 |
| 修稿时间： | 2004-07-30 |
Preparation and in vitro release of Niacin sustained-release tablets |
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| Wang Liqing,Jiang Ronggao,He Zhonggui. Preparation and in vitro release of Niacin sustained-release tablets[J]. Tianjin Pharmacy, 2004, 16(5): 2-4 |
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| Authors: | Wang Liqing Jiang Ronggao He Zhonggui |
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| Affiliation: | Wang Liqing1,Jiang Ronggao2,He Zhonggui2 |
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| Abstract: | Object: To prepare niacin sustained-release tablets and investigate in vitro release profile of the formulation. Methods: Matrix-based sustained-release niacin tablets were formulated using 4 kinds of HPMC with different viscosity. The effects of different dissolution media (water, 0.1 mol/L HCl and pH 6.8 phosphate buffer) on in vitro release were studied. Results: Our homemade niacin sustained-release tablets met the proposed standards for controlled-release products. Conclusions: The experimental formulation compared well with commercial product Niaspan(r). |
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| Keywords: | niacin sustained-release tablets preparation in vitro release |
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