Less severe retinopathy of prematurity induced by surfactant replacement therapy |
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Authors: | J Termote NE Schalij-Delfos BP Cats D Wittebol-Post BR Hoogervorst HAA Brouwers |
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Affiliation: | Department of Neonatology. University Hospital, Utrecht, The Netherlands;DepartmentComputer Division, Wilhelmina Children's Hospital, Utrecht,. University Hospital, Utrecht, The Netherlands;FC Donders Institute for Ophthalmology. University Hospital, Utrecht, The Netherlands |
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Abstract: | To assess the effect of surfactant replacement therapy (SRT) on the prevalence and severity of retinopathy of prematurity (ROP), we compared data from 160 SRT-treated preterm infants with data from 230 historic controls. The prevalence of ROP was 30.6% in the treatment group and 23.4% in the control group. Severe ROP (stages 3-4) was seen in 6.1% of the infants with ROP in the treatment group and 20.3% of the ROP patients in the control group. Surfactant therapy had no influence on the prevalence of ROP (odds ratio 1.4, 95% confidence interval 0.797-2.459, p = 0.242). However, SRT was associated with a decreased risk for severe ROP, compared to mild ROP (odds ratio 0.226, 95% confidence interval 0.056-0.905, p = 0.036). These data suggest that SRT is associated with a decreased risk for severe ROP. |
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Keywords: | Pulmonary surfactants respiratory distress syndrome retinopathy of prematurity |
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