地衣芽孢杆菌对非酒精性脂肪性肝病的治疗作用

目的探讨地衣芽孢杆菌制剂对非酒精性脂肪性肝病的治疗作用。方法选择正常健康人40例作为正常对照组。选择临床诊断非酒精性脂肪性肝病患者82例,随机将其分为易善复治疗组和易善复加整肠生治疗组,易善复治疗组41例,口服易善复456 mg,3次/d;易善复加整肠生治疗组41例,口服易善复456 mg及整肠生0.5 g,3次/d,两组均结合低热量饮食、运动等基础治疗,共6周。治疗前、后分别测定肝功能丙氨酸转移酶（ALT）、空腹胰岛素水平（FINS）、胰岛素敏感指数（ISI）、抵抗素（RETN）等。结果治疗前,易善复治疗组和易善复加整肠生治疗组FINS、ALT、RETN、ISI均高于正常对照组（P〈0.05）。治疗后,两治疗组FINS、ALT、RETN、ISI比治疗前降低（P〈0.05）,易善复加整肠生治疗组与易善复治疗组比较,差异有统计学意义（P〈0.05）。结论地衣芽孢杆菌制剂可减少非酒精性脂肪性肝病患者胰岛素抵抗（IR）,降低肠源性内毒素血症,改善肝功能,可作为非酒精性脂肪性肝病的药物治疗选择。

The effect of Bnfillus licheniformis on nonalcoholic fatty liver disease

Objective To evaluate the effect of Bnfillus licheniformis on nonalcoholic fatty liver disease(NAFLD).Methods 40 healthy volunteers were as normal control group.82 patients with nonalcoholic fatty liver disease were randomly divided into two groups: 41 patients received the treatment with polyene phosphatdyl choline(456 mg po,tid)(polyene phosphatdyl choline group);41 patients received polyene phosphatdyl choline(456 mg po,tid) and Bnfillus licheniformis(0.5 g po,tid)(polyene phosphatdyl choline and Bnfillus licheniformis group).The both groups were given low-calorie diet,exercise and other treatment for 6 weeks.The parameters were measured,which including fasting plasma resistin,insulin sensitive index(ISI) by fasting insulin(FINS),alanine aminotransferase(ALT) before and after treatment.Results Before treatment,FINS,ALT,ISI and RETN were higher in polyene phosphatdyl choline group and polyene phosphatdyl choline and Bnfillus licheniformis group than those in normal control group(P < 0.05).FINS,ALT,RETN and ISI significantly decreased(P < 0.05) after treatment.Polyene phosphatdyl choline and Bnfillus licheniformis group′s changes were more significant than those of polyene phosphatdyl choline group(P < 0.05).Conclusion Bnfillus licheniformis can decrease IR and the levels of serum endotoxin,improve liver function of NAFLD.It is a choice for NAFLD patients.