Effect of carnosine supplementation on lipid profile,fasting blood glucose,HbA1C and insulin resistance: A systematic review and meta-analysis of long-term randomized controlled trials |
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| Institution: | 1. Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran;2. Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, South Kargar Street, Tehran, Iran;3. Mental Health Research Center, School of Behavioral Sciences and Mental Health, Tehran Institute of Psychiatry, Iran University of Medical Sciences, Tehran, Iran;4. School of Persian Medicine, Iran University of Medical Sciences, Research Institute for Islamic and Complementary Medicine, Tehran, Iran;1. Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland;2. Department of Psychiatry, Kuopio University Hospital, KYS, P.O. Box 100, 70029, Finland;3. Department of Social Sciences, University of Eastern Finland, Kuopio, Finland;4. Primary Health Care Unit, University of Eastern Finland and Kuopio University Hospital, P.O. Box 1627, 70211 Kuopio, Finland;5. Department of Education and Psychology, University of Eastern Finland, P.O. Box 111, 80101 Joensuu, Finland;6. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland;7. Deakin University, iMPACT Institute, School of Medicine, P.O. Box 281, Geelong 3220, Australia;8. Metabolomics Unit, Institute for Molecular Medicine Finland FIMM, University of Helsinki, P.O. Box 20, 00014, Finland;9. Institute of Clinical Medicine, University of Oslo, Oslo, Norway;10. R&D department, Division of Mental Health Services, Akershus University Hospital, Lørenskog, Norway;11. Department of Psychiatry, University of Helsinki, Helsinki, Finland |
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| Abstract: | ObjectiveGlucose disorders and dyslipidemia are closely associated with obesity and metabolic disease. The purpose of this study was to investigate the effect of Carnosine supplementation on lipid profile, fasting blood glucose, HbA1C and Insulin resistance.MethodMEDLINE/PubMed, Scopus and Web of sciences were investigated to identify relevant articles up to June 2019. The search strategy combined the Medical Subject Heading and Title and/or abstract keywords. The combined effect sizes were calculated as weight mean difference (WMD) using the random-effects model. Between study heterogeneity was evaluated by the Cochran’s Q test and I2.ResultsFour RCTs studies investigated Carnosine use versus any control for at least 2 weeks were identified and analyzed. Overall results from the random-effects model on included studies, with 184 participants, indicated that carnosine intervention reduced HbA1C levels in intervention vs control groups (WMD: ?0.92 %, 95 % CI: ?1.20, ?0.63, I2:69 %). Four studies, including a total of 183 participants, reported TG changes as an outcome measure variable, but combined results did not show significant reduction in this outcome (WMD: ?14.46 mg/dl, 95 % CI: ?29.11, 0.19, I2:94 %). Furthermore, combined results did not show any significant change in HOMA-IR, Cholesterol, fasting blood sugar, or HDL-C.ConclusionCarnosine supplementation results in a decrease in HbA1C, but elicits no effect on HOMA-IR, Cholesterol, fasting blood sugar, TG and HDL-C. Future studies with a larger sample sizes, varied doses of carnosine, and population-specific sub-groups are warranted to confirm, and enhance, the veracity of our findings. |
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| Keywords: | Carnosine Cholesterol Fasting blood sugar HbA1C |
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