自噬与糖尿病肾病相关性研究进展

自噬是细胞为应对内外环境压力变化而出现的一种正常反应，是细胞内物质成分被溶酶体降解的过程。近年来研究发现，自噬在糖尿病肾病（DN）的发生发展中起着重要作用，是DN治疗的潜在靶点，与肾足细胞的生长发育和生理病理活动密切相关，是一种细胞的自我保护机制，调控自噬相关信号通路可影响DN发生发展。因此，本文就DN的发病机制、自噬在肾固有细胞中的作用以及调控自噬相关信号通路对糖尿病肾病发生发展的影响等方面进行综述。

Correlation of autophagy and diabetic nephropathy:research advances

Autophagy is a cellular normal reaction to cope with the changes in internal and external environmental pressure, and a degradation process of the material composition. Recent studies have shown that autophagy is closely related to the growth and physiological and pathological events of podocytes in kidneys and it is a potential target for the treatment of diabetic nephropathy(DN) and a self-protection mechanism. Rregulation of autophagy can affect some signaling pathways in the development of DN. Thus ,we summarize the pathogenesis of DN,the role of autophagy in the intrinsic kidney cells,and the effect of autophagy on some signaling pathways in the development of DN in this review.