适配体靶向肿瘤的纳米递送系统的研究进展 |
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引用本文: | 张兰馨,范田园.适配体靶向肿瘤的纳米递送系统的研究进展[J].国际药学研究杂志,2016(5):882-886. |
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作者姓名: | 张兰馨 范田园 |
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作者单位: | 北京大学药学院分子药剂学与新释药系统北京市重点实验室,北京,100191 |
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基金项目: | 北京市自然科学基金资助项目(7122101) |
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摘 要: | 核酸适配体是一类能特异性地靶向特定抗原的单链寡聚核苷酸。较之常用的抗体等靶头向性配体,适配体体积相对较小、免疫原性较低且易于体外筛选。目前,以适配体靶向肿瘤的纳米递送系统通常有3类:第1类将适配体修饰于脂质体、纳米粒、胶束等纳米载体上,形成适配体靶向的纳米载体;第2类直接将适配体与药物/荧光物质相连,形成适配体-药物/荧光物质共轭物;第3类将适配体自身作为药物的靶向载体。本文就近期以适配体靶向肿瘤的纳米递送系统的研究进展进行概述。
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关 键 词: | 适配体 肿瘤靶向 纳米载体 共轭物 组装物 |
Advances in nano-delivery systems based on aptamer targeting to tumor |
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Abstract: | Aptamers are kinds of single-strand oligonucleotides with high affinity to their targets. Compared to other commonly used target ligands,like antibodies,aptamers are small,non-immunogenic,as well as the undemanding in vitro screening. At pres?ent,the nano-delivery systems modified with aptamers for tumor targeting are often divided into three types:aptamers modifying on the surface of nanocarriers,such as liposomes,nanoparticles,and micelles,to form aptamer-targeted nanocarriers;aptamers conju?gating to molecular drugs or fluorescent agents to form aptamer-drug/fluorescent agent conjugates;and aptamers serving as drug carri?ers for further tumor targeting and drug delivery. In this paper,the advances in nano-delivery system based on aptamer targeting to tu?mor are summarized. |
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Keywords: | aptamer tumor-targeting nanocarriers conjugate assembly |
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