香加皮的化学成分及主要毒性研究进展

香加皮是萝摩科植物杠柳的干燥根皮，传统功能主治为祛风湿、强筋骨，近年来其抗肿瘤、抗慢性心衰等作用亦被认可。然而长期或大量服用香加皮可能产生的不良反应限制了其临床应用。因此，充分了解香加皮的化学成分谱，对全面理解香加皮致毒性的机制至关重要。目前已从香加皮中分离出近百个化学成分，但成分分类多样，且存在同物异名、结构名称混乱现象，均成为研究香加皮药效及毒性的一大障碍。本文对香加皮的94个化学成分进行了归类整理，并对其主要毒性研究进行了综述，旨在为香加皮的临床安全准确用药提供参考。

Chemical constituents of Cortex Periplocae Radicis and its main toxic ingredients:research advances

Cortex Periplocae Radicis(CPR)is the dried root barks of Periploca spium Bge. It has been used in China for treat?ing rheumatoid arthritis and strengthening the bone and the musculature for thousands of years. Recently,an increasing number of bio?activities of CPR have been recognized,including tumor suppression and anti-chronic heart failure function. However,long-term use or large doses of CPR may produce adverse reactions,which constrains its applications in clinical therapy. Therefore,it is critical to know the chemical components of CPR in order to understand the toxicity mechanism. Nearly a hundred chemical compositions have been found,however,various classes,obfuscated names of different compounds,and disaccord between chemical structure and name were major obstacles to studying pharmacodynamics and toxicity of CPR. In this paper,94 chemical components of CPR are classified and reviewed,which is valuable for the comprehensive understanding of its biological functions and safe clinical use.