| 焦亡在心脏疾病中的研究进展 |
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| 引用本文： | 郑嘉,秦颖,高硕阳,蒋雅楠,陈阳,王燕.焦亡在心脏疾病中的研究进展[J].国际遗传学杂志,2016(2):107-111. |
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| 作者姓名： | 郑嘉 秦颖 高硕阳 蒋雅楠 陈阳 王燕 |
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| 作者单位： | 1. 哈尔滨医科大学基础医学院病原生物学教研室,150081;2. 哈尔滨医科大学药学院,150081 |
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| 基金项目： | 国家自然科学基金面上项目(81271825)，黑龙江省自然科学基金(D201065)The National Natural Science Foundation of China (General Program)(81271825)，The Natural Science Foundation of Heilongjiang Province(D201065) |
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| 摘 要： | 焦亡是一种新发现并证实与炎症相关的细胞死亡方式,其特征为依赖于半胱天冬氨酸蛋白酶-1(cysteinyl aspartate specific proteinase-1,Caspase-1)的细胞程序性死亡,并伴有促炎症因子的释放,主要为白介素-1β(interleukin-1β,IL-1β)和白介素-18(interleukin-18,IL-18).越来越多的研究发现,焦亡相关信号通路在心脏疾病中起重要作用,包括心肌梗死、缺血再灌注损伤、心肌肥厚、心肌纤维化和心力衰竭等.本文就焦亡相关信号通路与心脏疾病关系研究进展作一综述.
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| 关 键 词： | 焦亡 心脏疾病 半胱天冬氨酸蛋白酶-1 白介素-1β 白介素-18 |
Progress in studying on pyroptosis-related signaling pathway in heart diseases |
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| Abstract: | Pyroptosis is a newly discovered and defined inflammation-related cell death,it is characterized by cysteinyl aspartate specific proteinase-1 (caspase-1)-depended programmed cell death which is a accompanied with the release of pro-inflammatory cytokines,mainly interleukin-1β (IL-1β) and IL-18.Increasing evidences suggest that pyroptosis-related signaling pathway plays important roles in myocardial infarction,ischemia/reperfusion,myocardial hypertrophy,myocardial fibrosis and heart failure,etc.This paper reviews the current understandings of pyroptosis-related signaling pathway in heart diseases. |
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| Keywords: | Pyroptosis Heart diseases Caspase-1 Interleukin-1β Interleukin-18 |
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