基于时间分辨透射光谱的血液血红蛋白无创检测方法

目的 基于时间分辨结合遮蔽光谱(TRACOS)技术进行血红蛋白在体无创测量方法的理论研究.方法 在人体手指部位及人工血流动力学条件下,检测和分析动态双波长时间分辨透射.通过对时域数据进行拉普拉斯变换,提高血红蛋白的检测灵敏度.使用质量浓度范围为6～16 g/dl的血红蛋白对时间分辨检测法进行验证.结果 模拟结果表明,与连续波法相比,当使用拉普拉斯变换参数p=5×1010 s-1时,时间分辨检测法可以提供更高的检测灵敏度.结论 采用小正参数对时间分辨透射光强进行拉普拉斯变换可以强调早到达光子效应,从而增强血红蛋白探测的灵敏度.

Non-invasive method of blood hemoglobin measurement based on time-resolved transmission spectroscopy

Objective To theoretically study the non-invasive measurement method of blood hemoglobin in vivo based on the time-resolved approach combined with occlusion spectroscopy.Methods The dynamic dual wavelength time-resolved transmission was analyzed based on the artificial blood flow kinetics condition on a human finger model.The sensitivity of hemoglobin measurement was improved by Laplace transforming of time-domain data.The method was validated using hemoglobin with a mass concentration range of 6～16 g/dl.Results The simulation results showed that compared with the continuous wave method,the time-resolved method could provide higher detection sensitivity using Laplace transform parameter p =5 × 1010 s-1.Conclusions The sensitivity of hemoglobin measurement can be enhanced when early arriving photons are emphasized by Laplace transformingthe time-resolved transmission with a small positive parameter.