脑脊液中红细胞清除速率与脑血管痉挛关系的实验研究

目的 研究实验性蛛网膜下腔出血(SAH)腰池持续引流后脑脊液中红细胞清除速率的变化及其与脑血管痉挛(CVS)的关系。方法 经皮枕大池二次注血法建立犬SAH动物模型,设立引流组、腰穿组和对照组,共18条狗,每组6条,动态测定脑脊液中红细胞量的变化,脑血管造影测定基底动脉直径减少以确定血管痉挛程度(％reduction of basilar artery diameter,％RBAD)。结果 与腰穿组和对照组相比,引流组脑脊液中红细胞清除速率较快且差异有显著性;引流组脑血管痉挛例数少,程度轻。结论 SAH后脑脊液中红细胞及其降解裂解产物可能参与了CVS的过程,腰池持续引流对CVS有防治作用。

Experimental study of relationship between cerebral vasospasm and clearance rate of red blood cell in cerebral spinal fluid following subarachnoid hemorrhage

Objective Investigation of the clearance rate of RBC in cerebral spinal fluid(CSF)after lumber subarachnoid space continuous drainage following subarachnoid hemorrhage(SAH)and the relationship with cerebral vasospasm(CVS) were carried out. Methods An experimental SAH was achieved in dogs by twice injecting fresh autologous arterial blood into cisterna magna of each animal.RBC counts in CSF were measured in the drainage group, puncture group and control group respectively.The degrees of CVS were analyzed through cerebral angiography(%reduction of basilar artery diameter,%RBAD). Results Comparing with puncture group and control group, the drainage group showed a significantly higher clearance rate of RBC with lesser occurrance and degree of CVS. Conclusions RBC and its degeneratives in CSF may be involed in the process of CVS following experimental SAH. Continuous lumber subarachnoid space drainage may prevent CVS.