Early bone reformation after cranial vault remodelling for sagittal craniosynostosis: A retrospective 3D analysis |
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| Affiliation: | 1. Cleft and Craniofacial SA, Women''s and Children''s Hospital, North Adelaide, South Australia, Australia;2. Division of Plastic Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;3. Biomechanics Research Center, Meticuly Co. Ltd., Chulalongkorn University, Bangkok, Thailand;4. Advanced Materials Analysis Research Unit, Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand;5. Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;6. Department of Neurosurgery, Women''s and Children''s Hospital, North Adelaide, South Australia, Australia;1. Department of Oral and Maxillofacial Surgery, National Cancer Center, Goyang, South Korea;2. BOS Research Institute, Seoul, South Korea;3. Department of Orthodontics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, South Korea;4. Department of Orthodontics, Eton Dental Clinic, South Korea;5. Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, South Korea;6. Dental Research Institute, Seoul National University, Seoul, South Korea;1. Department of Plastic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, South Korea;2. Department of Plastic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;3. Department of Electronic Engineering, Kwangwoon University, Seoul, South Korea;4. Graduate School of Smart Convergence, Kwangwoon University, Seoul, South Korea;1. Department of Oral and Maxillofacial Surgery, Helios Kliniken Schwerin, Wismarsche Straße 393-397, 19049, Schwerin, Germany;2. ISBA University of Cooperative Education, Ziegelseestr. 1, 19055, Schwerin, Germany;3. Department of Medical Biometry and Epidemiology, Eppendorf University Hospital, University of Hamburg, Martinistr. 52, D-20246, Hamburg, Germany;4. Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, Rostock University Medical Center, Schillingallee 35, 18057, Rostock, Germany;5. MKG-Praxis Am Stadthafen, Schliemannstraße 18, 19055, Schwerin, Germany;1. Department of Oral and Maxillofacial Surgery, Pontifical University Catholic of Rio Grande do Sul and São Lucas Hospital of PUCRS, Porto Alegre, Brazil;2. Department of Oral and Maxillofacial Surgery, Universitat Internacional de Catalunya, Sant Cugat del Valle’s and Institute of Maxillofacial Surgery, Teknon Medical Centre, Barcelona, Spain;3. Oral and Maxillofacial Surgeon, Private Practice, Valencia, Spain;4. Department of Orthodontics, Cardenal Herrera-CEU Universidad de Valencia, Valencia, Spain;5. Division of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, USA |
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| Abstract: | ![]()
This study aims to measure postoperative bone reformation percentage, rates and patterns after cranial vault remodelling (CVR) in isolated non-syndromic sagittal craniosynostosis. Volumetric bone measurements were performed starting from the DICOM files of previously available postoperative CT scans. The 3D images were then resampled into the master box, and ‘Skull 3D models’ were derived. The percentage of bone reformation was investigated using automated 3D analysis software. The intra-rater reliability analysis revealed high reliability (Intraclass correlation coefficient = 0.99, p < 0.001). The median bone reformation volume and rate were 11.2 ml and 1.98 ml/week, respectively. The median percentage of bone reformation was 56.7% when the median postoperative CT timing was 6.1 weeks. As a statistic model, the linear plateau showed the highest Pseudo R2 in both volume and percentage of bone reformation predicting patterns. By using the calculated model at 9 weeks postoperatively, the re-osteogenesis reaches 80% of the total cranial defect. After CVR, the early bone reformation pattern was demonstrated as a linear plateau model rather than logarithmic. This study gives a better understanding of the pattern and quantity of re-osteogenesis at cranial defects after CVR. The statistic model can facilitate healthcare practitioners to predict bone reformation and improve postoperative care protocol in sagittal craniosynostosis management. |
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| Keywords: | Craniosynostosis Cranial Osteogenesis 3D analysis Craniofacial abnormalities |
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