MEF2 in cardiac hypertrophy in response to hypertension |
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Institution: | 1. Department of Biology, York University, Toronto, ON M3J 1P3, Canada;2. Muscle Health Research Centre (MHRC), York University, Toronto, ON M3J 1P3, Canada;3. Centre for Research in Biomolecular Interactions (CRBI), York University, Toronto, ON M3J 1P3, Canada |
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Abstract: | Hypertension is a globally prevalent pathological condition and an underlying risk factor for the development of cardiac hypertrophy leading to heart failure. Myocyte enhancer factor 2 (Mef2) has been identified as one of the primary effectors of morphological changes in the hypertensive heart, as part of a complex network of molecular signaling controlling cardiac gene expression. Experimental chronic pressure-overload models that mimic hypertension in the mammalian heart lead to the activation of various pathological mechanisms that result in structural changes leading to debilitating cardiac hypertrophy and ultimately heart failure. The purpose here is to survey the literature implicating Mef2 in hypertension induced cardiac hypertrophy, towards illuminating points of interest for understanding and potentially treating heart failure. |
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