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Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
Institution:1. Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;2. Division of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA;3. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, and Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, CB2 0AW, UK;4. Division of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, 10090, Austria;5. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA;6. Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA;7. Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA;8. Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands;9. Institute of Clinical Molecular Biology, University of Kiel, 24105 Kiel, Germany;10. Department of Internal Medicine, Division of Gastroenterology and Hepatology, Michigan Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA;11. Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland;12. Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland;13. Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA;14. Department of Medicine, Pediatrics and Committee on Genetics, The University of Chicago, Chicago, IL 60637, USA;15. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;16. Research Centre for Infectious Diseases, Department of Molecular and Biomedical Science, the University of Adelaide, Adelaide, 5005, Australia;17. Massachusetts Host-Microbiome Center, Department of Pathology, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;18. Howard Hughes Medical Institute, Boston, MA 02115, USA;1. Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;2. Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;3. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;4. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China;1. University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA;2. University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA;3. University of California, San Francisco, Oral and Craniofacial Sciences Graduate Program, San Francisco, CA 94143, USA;4. University of California, Los Angeles, Department of Infectious Diseases, Los Angeles, CA 90095, USA;5. Department of Dermatology, Meyer Cancer Center, Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA;6. Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY, USA;7. Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA;8. Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA;1. Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia;2. Centre for Experimental Immunology, Lions Eye Institute, Nedlands, WA, Australia;3. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA;4. Monash Bioinformatics Platform, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia;5. Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA, USA;6. Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA;1. QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia;2. School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia;3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh;4. School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD 4000, Australia;5. School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia;6. University of Queensland Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Brisbane, QLD 4102, Australia;7. Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia;8. Mater Research Institute, The University of Queensland, Translational Research Institute, Wolloongabba, Brisbane, QLD 4102, Australia;9. Hunter Medical Research Institute, Newcastle, NSW, Australia;10. Princess Alexandra Hospital, Brisbane, QLD, Australia;11. The School of Earth and Environmental Sciences, The University of Queensland, Brisbane, QLD 4072, Australia;12. Microba Life Sciences, Translational Research Institute, Woolloongabba, Brisbane, QLD 4102, Australia;13. Telethon Kids Institute, The University of Western Australia, Nedlands, WA 6009, Australia;1. Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK;2. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Trinity College, Dublin D08 W9RT, Ireland;3. Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK;4. Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Salford M6 8HD, UK;5. JJP Biologics, Warsaw, Poland;6. Department of Pathology & Immunology, Washington University, St. Louis, MO 63110, USA;1. Institute of Medical Microbiology, RWTH University Hospital, Aachen, Germany;2. Pediatrics Department, Infectious Disease Section, UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
Abstract:
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  • Keywords:TH17 cells  epithelial endoplasmic reticulum stress  ROS signals  purine metabolism  commensal bacterial  Citrobacter rodentium  inflammatory bowel disease
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